Using repeated measures of symptom score, uroflowmetry and prostate specific antigen in the clinical management of prostate disease. Benign Prostatic Hyperplasia Treatment Outcomes Study Group

The Journal of Urology
M J BarryH A Guess

Abstract

Measurements of American Urological Association symptom score, peak urine flow rate and prostate specific antigen (PSA) are often followed over time in urological management. However, their interpretation is confounded by within-patient variability due to chance. Data from 2 clinical trials are used to examine the magnitude of this variation. When these measures are repeated at a short interval variation is modest and might easily be misinterpreted as a true change in patient condition. For example, approximately 20% of patients might be expected to have a chance increase or decrease in symptom score by at least 4.9 points, in peak urine flow rate by at least 4.1 ml. per second or in PSA by at least 1.6 ng./ml. Clinicians can use these data to help interpret repeated measures of these variables in patients, and can consider obtaining paired measurements to decrease the effect of chance variation when they plan on following them over time.

References

Apr 22, 1992·JAMA : the Journal of the American Medical Association·H B CarterP C Walsh
Oct 22, 1992·The New England Journal of Medicine·G J GormleyJ S Tenover
Dec 1, 1988·British Journal of Urology·N C BirchP T Doyle
May 1, 1986·Journal of Clinical Periodontology·N W Chilton, J L Fleiss
Feb 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G M CostongsJ W van Wersch
Jul 1, 1985·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·G M CostongsJ W van Wersch
Aug 18, 1993·JAMA : the Journal of the American Medical Association·J E OesterlingM M Lieber
Sep 1, 1993·The Journal of Urology·C J GirmanM M Lieber
Oct 1, 1993·Urology·M RiehmannR C Bruskewitz

❮ Previous
Next ❯

Citations

Jan 1, 1997·Urological Research·J L Ruud Bosch
Sep 1, 1996·Journal of General Internal Medicine·J B MeigsS J Jacobsen
Jun 27, 2002·Current Urology Reports·C E Kelly, R J Krane
May 20, 1998·Urology·J V Jepsen, R C Bruskewitz
Apr 11, 2000·BJU International·G Williams
Nov 1, 1995·British Journal of Urology·R J Prescott, W M Garraway
Nov 13, 2004·Urologia Internationalis·W Al-SingaryH R H Patel
Feb 14, 2016·Urology·Christopher A TamUNKNOWN Trauma and Urologic Reconstruction Network of Surgeons (TURNS)
Feb 26, 1999·The Journal of Urology·C KolmanM M Lieber
Jun 1, 1996·Hematology/oncology Clinics of North America·J O Jacobson
Feb 23, 1999·The Urologic Clinics of North America·J V Jepsen, R C Bruskewitz
Jul 12, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Jiro UozumiZenjiro Masaki
Aug 1, 1997·The Journal of Urology·S J JacobsenM M Lieber
Jun 21, 2006·Neurotoxicity Research·G BrisindaA Albanese
Aug 5, 2000·Current Opinion in Urology·M R Feneley, A W Partin
Jan 20, 2011·BJU International·Flavio L HeldweinClaudio Teloken
May 15, 2003·Scandinavian Journal of Urology and Nephrology·R Corey O'ConnorGlenn S Gerber

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.