Using salmonid microarrays to understand the dietary modulation of carcinogenesis in rainbow trout

Toxicological Sciences : an Official Journal of the Society of Toxicology
Evan P Gallagher

Abstract

The highlighted article in this issue by Tilton et al. (2005a) is an innovative approach to evaluate the modulation of estrogen receptor (ER) and aryl hydrocarbon (Ah)-receptor pathways as mechanisms underlying indole-3-carbinol (I3C) tumor promotion in rainbow trout (Onchorhynchus mykiss). I3C and its major in vivo component 3,3'-diindolylmethane (DIM) are potent tumor promoters that appear to target both of the aforementioned receptor pathways. However, the relative importance of I3C modulation of ER and AhR-dependent pathways in the promotion of rainbow trout hepatocarcinogenesis has not been established. Previously, researchers within this group reported that I3C promotes aflatoxin B1 (AFB1)-induced trout hepatocarcinogenesis post-initiation at low concentrations in the diet that induce the expression of vitellogenin, a downstream marker for the activation of ER-dependent pathways in fish. Furthermore, the promotional effects of I3C on AFB1 hepatocarcinogenesis in rainbow trout occur at concentrations that differentially induce vitellogenin, but not CYP1A expression. Interestingly, higher I3C concentrations induce the expression of both CYP1A and vitellogenin. Thus, the relative induction of vitellogenin and CYP1A expressio...Continue Reading

References

Apr 1, 1987·Environmental Health Perspectives·G BaileyJ Hendricks
Feb 24, 2001·Drug Metabolism and Drug Interactions·H G Shertzer, A P Senft
Jun 15, 2005·BMC Physiology·Nina StåhlbergAmilcar Flores-Morales
Sep 6, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Susan C TiltonDavid E Williams

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Citations

Dec 15, 2010·International Journal of Molecular Sciences·Cheng-Hua HeHai-Bin Zhang
Nov 6, 2007·Molecular Nutrition & Food Research·Mendel FriedmanGeorge S Bailey
Sep 25, 2014·Journal of Exposure Science & Environmental Epidemiology·Mustafa T YıldızgörenLevent Ozçakar

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