Using signaling pathways to overcome immune tolerance to tumors

Science's STKE : Signal Transduction Knowledge Environment
Edgar G EnglemanLuis Soares

Abstract

The ability of tumors to evade the immune system is thought to result from the inability of T lymphocytes to recognize and respond to tumor antigens. This lack of T cell response may depend on a failure of dendritic cells to present antigen in the proper context so that T cells become tolerant to tumor antigens rather than primed to undergo an immune response. The inability of tumor-associated dendritic cells to effectively present antigen may in turn depend on inhibitory factors in the tumor milieu. Recent experiments suggest that the administration of toll-like receptor ligands stimulate dendritic cell activation and maturation and may thus help overcome T cell tolerance to tumor antigens. Whether or not such an approach is clinically feasible remains to be seen.

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Citations

Feb 14, 2006·Journal of Virology·Maryam AhmedElizabeth M Hiltbold
Sep 16, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yu LiuRongcun Yang
Sep 1, 2005·Immunology Letters·George Klein, Eva Klein
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Apr 28, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hisashi SajiEdgar G Engleman

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