Using Small Samples to Evaluate Normative Reference Ranges for Retinal Imaging Measures

Optometry and Vision Science : Official Publication of the American Academy of Optometry
William H SwansonDouglas G Horner

Abstract

Retinal nerve fiber layer (RNFL) deviation maps often incorrectly score healthy eyes as having wedge defects. This study shows how to identify such problems early in the development of normative databases. After reference values are embedded in devices, clinicians and researchers often learn about issues that cause false-positive rates in healthy eyes. Here we show a way to detect and address such issues early on. The thickness of the RNFL was measured for both eyes of 60 healthy younger adults aged 20 to 31 years and one eye each of 30 healthy older adults aged 54 to 82 years. Deviation maps were developed from the left eyes of the first 30 younger adults, and between-subject variability in the shape of the RNFL was assessed. This was repeated in their right eyes, in the second group of younger adults and in the older adults. For the first group of 30 healthy young adults, between-subject variability in the location of the region of greatest thickness meant that 58% of the pixels below the fifth percentile in the left eyes were from four people whose deviation maps had wedge-shaped patterns, as did the deviation maps for the nine right eyes with 87% of the pixels below the fifth percentile. Wedge patterns were also seen in dev...Continue Reading

References

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A T FunkhouserR A Weale
Oct 1, 1990·The Journal of Comparative Neurology·C A Curcio, K A Allen
Feb 1, 1989·Archives of Ophthalmology·A Heijl, P Asman
Aug 1, 1985·The Journal of Comparative Neurology·J M ProvisP Russell
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Paul H ArtesBalwantray C Chauhan
Jan 18, 2011·American Journal of Ophthalmology·Jean-Claude MwanzaUNKNOWN Cirrus OCT Normative Database Study Group
Feb 26, 2011·The British Journal of Ophthalmology·Giacomo SaviniMichele Carbonelli
Mar 2, 2011·Investigative Ophthalmology & Visual Science·Andrew Turpin, Allison M McKendrick
Nov 23, 2011·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Nimesh B PatelRonald S Harwerth
Jan 21, 2012·Current Opinion in Ophthalmology·Gabriel T Chong, Richard K Lee
Sep 22, 2012·Investigative Ophthalmology & Visual Science·Christopher Kai-Shun LeungDennis Shun-Chiu Lam
Feb 15, 2014·JAMA Ophthalmology·Sanjay AsraniCecilia Santiago-Turla
Apr 15, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Muhammed S AlluwimiVictor E Malinovsky
Sep 27, 2014·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William H SwansonDouglas G Horner
Jun 3, 2015·Journal of Glaucoma·Corinne MauriceEytan Z Blumenthal
Feb 14, 2016·Investigative Ophthalmology & Visual Science·Bright S Ashimatey, William H Swanson
Mar 16, 2016·Investigative Ophthalmology & Visual Science·Stuart K GardinerBrad Fortune
Nov 24, 2017·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Bright S AshimateyWilliam H Swanson
Jan 10, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Muhammed S AlluwimiBrett J King
Mar 22, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Bright S AshimateyWilliam H Swanson
Mar 27, 2018·Translational Vision Science & Technology·Muhammed S AlluwimiBrett J King

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Citations

Oct 17, 2019·PloS One·William H SwansonStephen A Burns
Feb 6, 2020·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Brett J KingTodd D Peabody
Aug 21, 2020·Translational Vision Science & Technology·Emmanouil TsamisDonald C Hood
May 12, 2021·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William H SwansonStephen A Burns

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