Using standard nomenclature to adequately name transgenes, knockout gene alleles and any mutation associated to a genetically modified mouse strain.

Transgenic Research
Lluís Montoliu, C Bruce A Whitelaw

Abstract

Mice provide an unlimited source of animal models to study mammalian gene function and human diseases. The powerful genetic modification toolbox existing for the mouse genome enables the creation of, literally, thousands of genetically modified mouse strains, carrying spontaneous or induced mutations, transgenes or knock-out/knock-in alleles which, in addition, can exist in hundreds of different genetic backgrounds. Such an immense diversity of individuals needs to be adequately annotated, to ensure that the most relevant information is kept associated with the name of each mouse line, and hence, the scientific community can correctly interpret and benefit from the reported animal model. Therefore, rules and guidelines for correctly naming genes, alleles and mouse strains are required. The Mouse Genome Informatics Database is the authoritative source of official names for mouse genes, alleles, and strains. Nomenclature follows the rules and guidelines established by the International Committee on Standardized Genetic Nomenclature for Mice. Herewith, both from the International Society for Transgenic Technologies (ISTT) and from the scientific journal Transgenic Research, we would like to encourage all our colleagues to adhere a...Continue Reading

References

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Citations

Feb 4, 2012·Transgenic Research·Michael StaudtJohannes Schenkel
Oct 20, 2012·Gastroenterology·Malcolm J Low
Nov 1, 2016·Journal of Neurochemistry·Steven W Barger
Feb 16, 2017·Annual Review of Animal Biosciences·Stacey J Sukoff Rizzo, Jacqueline N Crawley
Mar 21, 2019·Animal Models and Experimental Medicine·Qi Kong, Chuan Qin
Jul 15, 2020·PLoS Biology·Nathalie Percie du SertHanno Würbel
Sep 19, 2021·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M-C BirlingL Teboul

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