Using Swiss Webster mice to model Fetal Alcohol Spectrum Disorders (FASD): An analysis of multilevel time-to-event data through mixed-effects Cox proportional hazards models

Behavioural Brain Research
Carlita B FaveroCarlita Favero

Abstract

Fetal Alcohol Spectrum Disorders (FASD) collectively describes the constellation of effects resulting from human alcohol consumption during pregnancy. Even with public awareness, the incidence of FASD is estimated to be upwards of 5% in the general population and is becoming a global health problem. The physical, cognitive, and behavioral impairments of FASD are recapitulated in animal models. Recently rodent models utilizing voluntary drinking paradigms have been developed that accurately reflect moderate consumption, which makes up the majority of FASD cases. The range in severity of FASD characteristics reflects the frequency, dose, developmental timing, and individual susceptibility to alcohol exposure. As most rodent models of FASD use C57BL/6 mice, there is a need to expand the stocks of mice studied in order to more fully understand the complex neurobiology of this disorder. To that end, we allowed pregnant Swiss Webster mice to voluntarily drink ethanol via the drinking in the dark (DID) paradigm throughout their gestation period. Ethanol exposure did not alter gestational outcomes as determined by no significant differences in maternal weight gain, maternal liquid consumption, litter size, or pup weight at birth or wea...Continue Reading

References

Dec 1, 1995·American Journal of Public Health·N L Day
May 15, 1998·Alcoholism, Clinical and Experimental Research·S N Mattson, E P Riley
Dec 21, 2000·Statistics in Medicine·F Vaida, R Xu
Mar 23, 2002·Annual Review of Public Health·Thomas LumleyLu Chen
Dec 24, 2003·Alcoholism, Clinical and Experimental Research·Andrea M AllanKevin K Caldwell
Jan 12, 2005·Physiology & Behavior·Justin S RhodesJohn C Crabbe
Jan 18, 2005·Alcoholism, Clinical and Experimental Research·Feng C ZhouTeresa A Powrozek
Feb 22, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Verginia C CuzonHermes H Yeh
Aug 7, 2008·Developmental Psychobiology·Stephen L BoehmDavid N Linsenbardt
Mar 31, 2009·Research in Developmental Disabilities·Jacquelyn Bertrand, UNKNOWN Interventions for Children with Fetal Alcohol Spectrum Disorders Research Consortium
Jun 24, 2009·Neuroscience and Biobehavioral Reviews·Kim G C HellemansJoanne Weinberg
Jul 16, 2010·Alcoholism, Clinical and Experimental Research·Daniel D SavageDerek A Hamilton
May 24, 2011·Behavioural Brain Research·Morgan L KleiberShiva M Singh
Mar 10, 2012·Trends in Neurosciences·C Fernando ValenzuelaLauren Topper
Jul 26, 2012·BJOG : an International Journal of Obstetrics and Gynaecology·K K SulikE P Riley
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karina Possa AbrahaoJeffrey L Weiner
Jun 13, 2013·Behavioural Brain Research·Michelle C Sanchez VegaThomas H J Burne
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hani El ShawaKelly J Huffman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.