Using synchrotrons and XFELs for time-resolved X-ray crystallography and solution scattering experiments on biomolecules

Current Opinion in Structural Biology
Matteo LevantinoArwen R Pearson

Abstract

Time-resolved structural information is key to understand the mechanism of biological processes, such as catalysis and signalling. Recent developments in X-ray sources as well as data collection and analysis methods are making routine time-resolved X-ray crystallography and solution scattering experiments a real possibility for structural biologists. Here we review the information that can be obtained from these techniques and discuss the considerations that must be taken into account when designing a time-resolved experiment.

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