Using the Coriell Personalized Medicine Collaborative Data to conduct a genome-wide association study of sleep duration

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics
Laura ScheinfeldtMichael F Christman

Abstract

Sleep is critical to health and functionality, and several studies have investigated the inherited component of insomnia and other sleep disorders using genome-wide association studies (GWAS). However, genome-wide studies focused on sleep duration are less common. Here, we used data from participants in the Coriell Personalized Medicine Collaborative (CPMC) (n = 4,401) to examine putative associations between self-reported sleep duration, demographic and lifestyle variables, and genome-wide single nucleotide polymorphism (SNP) data to better understand genetic contributions to variation in sleep duration. We employed stepwise ordered logistic regression to select our model and retained the following predictive variables: age, gender, weight, physical activity, physical activity at work, smoking status, alcohol consumption, ethnicity, and ancestry (as measured by principal components analysis) in our association testing. Several of our strongest candidate genes were previously identified in GWAS related to sleep duration (TSHZ2, ABCC9, FBXO15) and narcolepsy (NFATC2, SALL4). In addition, we have identified novel candidate genes for involvement in sleep duration including SORCS1 and ELOVL2. Our results demonstrate that the self-r...Continue Reading

References

Dec 18, 2004·Drug News & Perspectives·Oscar Prospéro-García, Mónica Méndez-Díaz
Mar 31, 2005·Seminars in Neurology·Jeffrey S Durmer, David F Dinges
Apr 20, 2007·Sleep Medicine Reviews·Kristen L KnutsonEve Van Cauter
Apr 26, 2007·Annals of Medicine·Timo PartonenGunter Schumann
Oct 16, 2007·BMC Medical Genetics·Daniel J GottliebJemma B Wilk
Mar 21, 2009·American Journal of Epidemiology·Patrick M Krueger, Elliot M Friedman
Mar 25, 2010·The Journal of Clinical Psychiatry·Josine G van MillBrenda W J H Penninx
May 4, 2010·Nature Biotechnology·Cory Y McLeanGill Bejerano
Jan 15, 2011·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Catharine B StackMargaret A Keller
Jul 15, 2011·The Open Respiratory Medicine Journal·Laila Aldabal, Ahmed S Bahammam
Feb 4, 2012·Frontiers in Genetics·Laura B ScheinfeldtJoshua M Akey
Oct 16, 2012·Aging Cell·Paolo GaragnaniClaudio Franceschi
Nov 7, 2012·Nature·UNKNOWN 1000 Genomes Project ConsortiumGil A McVean
Mar 2, 2013·Sleep·Daniel S EvansUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Group
Jun 4, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Enda M ByrneUNKNOWN Chronogen Consortium
Jan 24, 2014·Clinical Medicine Insights. Case Reports·James W Butterworth, John M Shneerson
Feb 21, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Laura DumasJames M Sikela
Aug 12, 2014·Journal of Sleep Research·Hanna M OllilaTiina Paunio
May 1, 2010·Personalized Medicine·Margaret A KellerMichael F Christman

❮ Previous
Next ❯

Citations

Apr 29, 2016·Thrombosis and Haemostasis·Payman ShahabiNeda Gharani
May 23, 2016·Journal of Neuropathology and Experimental Neurology·Peter T NelsonEseosa T Ighodaro
Aug 17, 2016·International Journal of Molecular Sciences·Laura B ScheinfeldtMichael F Christman
Mar 23, 2017·Current Opinion in Neurobiology·Guangsen ShiYing-Hui Fu
Dec 21, 2017·Biological Research for Nursing·Veronica Barcelona de MendozaJacquelyn Y Taylor
Dec 2, 2017·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Whitney E Melroy-GreifCindy L Ehlers
Mar 10, 2018·Molecular Psychiatry·Murray B SteinRobert J Ursano
Feb 2, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Ji Yao ZhangJ Thomas Brenna
Apr 29, 2020·Journal of Personalized Medicine·Tara SchmidlenLaura B Scheinfeldt
May 1, 2016·Personalized Medicine·Susan K Delaney, Michael F Christman
Jul 16, 2019·Journal of Circadian Rhythms·Tricia D LeVanAnn M Berger
Aug 6, 2017·Sleep Medicine Clinics·Namni Goel

❮ Previous
Next ❯

Methods Mentioned

BETA
PCA
Genotyping

Software Mentioned

GREAT
Beagle
R
MASS
MASS R package
PLINK
R script
polr

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.