PMID: 22576426May 12, 2012Paper

Using the interrupter technique to evaluate airway resistance in cystic fibrosis patients

Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia
Alessandra RochaPaulo José Cauduro Marostica

Abstract

To measure airway resistance with the interrupter resistance (Rint) technique in patients with cystic fibrosis (CF) and to determine whether Rint values correlate with spirometric parameters, as well as to evaluate the accuracy of the Rint technique in determining the airway response to a bronchodilator. This was a cross-sectional study involving 38 children and adolescents with CF followed at the Cystic Fibrosis Outpatient Clinic of the São Lucas Hospital, located in the city of Porto Alegre, Brazil. After Rint had been measured, the subjects underwent spirometry. To evaluate bronchodilator response, we repeated the measurements after the use of inhaled albuterol. There was a strong correlation between inverse Rint and FEV1 (r = 0.8; p < 0.001), and there was a moderate correlation between inverse Rint and FEF25-75% (r = 0.74; p < 0.001), as well as between inverse Rint and body mass index (r = 0.62; p < 0.001). We used a ROC curve to compare the bronchodilator response, as determined by Rint, with spirometric values. For a Rint cut-off point of -28%, the area under the curve was 0.75, with a sensitivity of 66% and a specificity of 82%. Our findings suggest that Rint correlates well with spirometric parameters, although the Ri...Continue Reading

References

Apr 23, 1999·Pediatric Pulmonology·S KannistoM Korppi
May 23, 2002·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonUNKNOWN French Pediatric Programme Hospitalier de Recherche Clinique Group
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonClaude Gaultier
Jul 19, 2003·American Journal of Respiratory and Critical Care Medicine·Nicole BeydonUNKNOWN French Paediatric Programme Hospitalier de Recherche Clinique Group
Jun 27, 2006·Paediatric Respiratory Reviews·Nicole Beydon
Nov 16, 2006·Pediatric Pulmonology·Philip L DaviesFrances Child

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Citations

Nov 19, 2019·Current Opinion in Critical Care·Giacomo GrasselliAlberto Zanella
Jun 24, 2016·Science Translational Medicine·Johanna F DekkersJeffrey M Beekman

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