Using the Kinetic Estimating Glomerular Filtration Rate Equation for Estimating Glomerular Filtration Rate and Detecting Acute Kidney Injury: A Pilot Study

Nephron
Manohar BairyRu Sin Lim

Abstract

Estimating the glomerular filtration rate (eGFR) when the creatinine (Cr) is rapidly changing, as in acute kidney injury (AKI), has been a challenge. The Kinetic Estimated Glomerular Filtration Rate (KeGFR) formula by S. Chen estimates the GFR in the acute state by factoring the time interval between rising Cr values and the volume of distribution (VD). It provides the clinician with an eGFR value for each non-steady state Cr value. We applied the KeGFR formula to detect AKI in an adult non-ICU inpatient setting. We then compared KeGFR with the current standard Acute Kidney Injury Network (AKIN criteria) and Risk Injury Failure Loss End-Stage Kidney Disease (RIFLE criteria) and new criteria (Waikar-Bonventre, Delta check) for AKI detection. A total of 250 consecutive adult patients admitted to the Medical wards were screened. Patient episodes with a change in Cr of > 4.3% (Biological Variation) were included in the study (n = 80). The KeGFR equation was applied to this cohort after calculating the VD individually after estimating the initial GFR by using MDRD equation. A fall in KeGFR of 25% or more was considered as AKI. The AKIN, Waikar-Bonventre, RIFLE, and Delta Check criteria were also applied to this cohort and compared w...Continue Reading

Citations

Jan 12, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Lavanya BathiniAmit X Garg
May 22, 2020·Indian Journal of Pediatrics·Akarsh Vijayakumar LathaTanveer Rehman
Nov 6, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Karyne PelletierJosée Bouchard
Jan 16, 2021·Pediatric Research·Minnie N DasguptaScott M Sutherland
Jun 28, 2021·Nephrology·Daniel ChristiadiZoltán Endre

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sean M BagshawBeginning and Ending Supportive Therapy for the Kidney (BEST Kidney) Investigators
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Shaobin DuanFuyou Liu
Critical Care : the Official Journal of the Critical Care Forum
Xuying LuoXiuming Xi
© 2022 Meta ULC. All rights reserved