DOI: 10.1101/479303Nov 26, 2018Paper

Using the modified male osteoporosis self-assessment tool for Taiwan to predict osteoporosis onset – a sub-study of the Taiwan osteoporosis survey

BioRxiv : the Preprint Server for Biology
Ying-Chou ChenChung-Yuan Hsu

Abstract

Purpose To develop a risk index by item reduction from multiple variable regression, which can identify male Taiwanese patients at risk of developing osteoporosis. Methods To develop the model, a risk index was identified by item reduction from multivariate regression analysis. Using receiver operating characteristic (ROC) curve analysis and their sensitivity/specificity, MOSTAi was validated in a separate cohort of Taiwanese men and its performance with compared with the National Osteoporosis Foundation recommendations (NOF 2013). Results Between 2008 and 2011 a total of 4,323 males were enrolled for bone mineral density (BMD) measurements. Univariate analysis identified four major risk factors for osteoporosis, including age, body weight (BW), previous fracture and body height. The ROC analysis showed the area under the curve (AUC) for the model based on the three-variable, two-variable (age and BW), and one-variable models (BW), was 0.701 (p<0.001, 95% confidence interval [CI] 0.658-0.744), 0.700 (p<0.001, 95% CI, 0.656-0.742), and 0.690 (p<0.001, 95% CI, 0.646-0.734), respectively. Using the optimal cutoff value (-2) for the OSTA, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (N...Continue Reading

Related Concepts

Bone Density
Fracture
Male Population Group
Osteoporosis
Scanning
Cohort
Univariate Analysis
Analysis
Race - Taiwanese
Study

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