PMID: 11918465Mar 29, 2002Paper

Using the new antiepilepsy drugs in children

Journal of Child Neurology
James W Wheless

Abstract

New epilepsy treatment options are becoming available to physicians and may help provide safe and effective seizure management in patients for whom traditional drug therapies have been unsuccessful. Presented here is a brief discussion on the screening models used to test drugs for efficacy against various seizure types and the mechanisms of action and pharmacology of antiepilepsy drugs. This is followed by a more detailed review of the clinical pharmacology of the latest three antiepilepsy drugs introduced to the United States: levetiracetam, oxcarbazepine, and zonisamide. All three appear to have advantages over some traditional antiepilepsy drugs and with more clinical experience may replace them in certain seizure types or epilepsy syndromes.

References

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Jun 14, 2000·Seizure : the Journal of the British Epilepsy Association·S Shorvon
Oct 18, 2000·Pediatric Neurology·T KishiK Ueda
Nov 4, 2000·Expert Opinion on Investigational Drugs·K K Jain
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Apr 16, 2002·Journal of Child Neurology·Tracy A Glauser, John M Pellock
Jul 5, 2005·Expert Opinion on Investigational Drugs·S C Schachter

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Citations

May 8, 2007·Expert Opinion on Drug Safety·Sanjeev V Kothare, Joseph Kaleyias
May 8, 2007·Expert Opinion on Drug Safety·Deepa Sirsi, Joseph E Safdieh
Jan 30, 2007·Seizure : the Journal of the British Epilepsy Association·D PeakeS Philip
Jan 23, 2009·International Journal of Occupational Medicine and Environmental Health·Adrianna PotockaMarta Kieć-Swierczyńska

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