Using the NIH Research, Condition and Disease Categorization Database for research advocacy: Schizophrenia research at NIMH as an example

PloS One
E Fuller TorreyD J Jaffe

Abstract

In 2008 the National Institutes of Health established the Research, Condition and Disease Categorization Database (RCDC) that reports the amount spent by NIH institutes for each disease. Its goal is to allow the public "to know how the NIH spends their tax dollars," but it has been little used. The RCDC for 2018 was used to assess 428 schizophrenia-related research projects funded by the National Institute of Mental Health. Three senior psychiatrists independently rated each on its likelihood ("likely", "possible", "very unlikely") of improving the symptoms and/or quality of life for individuals with schizophrenia within 20 years. At least one reviewer rated 386 (90%), and all three reviewers rated 302 (71%), of the research projects as very unlikely to provide clinical improvement within 20 years. Reviewer agreement for the "very unlikely" category was good; for the "possible" category was intermediate; and for the "likely" category was poor. At least one reviewer rated 30 (7%) of the research projects as likely to provide clinical improvement within 20 years. The cost of the 30 projects was 5.5% of the total NIMH schizophrenia-related portfolio or 0.6% of the total NIMH budget. Study results confirm previous 2016 criticisms t...Continue Reading

References

May 16, 2006·Schizophrenia Bulletin·Paul Fearon, Craig Morgan
Mar 16, 2013·The Milbank Quarterly·Bhaven N SampatMarcel Perl
Jul 1, 2014·Academic Medicine : Journal of the Association of American Medical Colleges·Bridget C O'BrienDavid A Cook
Nov 27, 2015·Schizophrenia Research·Faith DickersonRobert Yolken
May 3, 2016·The Journal of Clinical Psychiatry·Martin CloutierEric Wu
Jun 3, 2016·The British Journal of Psychiatry : the Journal of Mental Science·Roberto Lewis-FernándezPortia Iversen
Dec 8, 2017·JAMA Psychiatry·Hannah E JongsmaUNKNOWN European Network of National Schizophrenia Networks Studying Gene-Environment Interactions Work Package 2 (EU-GEI WP2) Group

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