Using the Rubik's Cube to directly produce paper analytical devices for quantitative point-of-care aptamer-based assays

Biosensors & Bioelectronics
Haiyan FuYun Zhang

Abstract

In this article, we describe a facile method named as Rubik's Cube stamping (RCS) for equipment-free fabrication of microfluidic paper-based analytical devices (μPADs). RCS is inspired by the worldwide ubiquitous RC toy and requires no specialized electric equipment other than a classical six-faced RC that is assembled with home-made small iron components. It can pattern various rosin microstructures in paper simply by either using different functional faces of the modified RC or applying its internal pivot mechanism to adjust the components' patterning forms on one functional face. Such a versatile stamping method is quite simple and inexpensive, and thus holds potential for producing rosin-patterned μPADs by untrained users in resource-limited environments such as small laboratories and private clinics, or even at home and in the field. Moreover, a set of one-channel devices are fabricated to design a point-of-care aptamer-based assay with near sample-in-answer-out capability that integrates enzymatic reactions for robust yet efficient signal amplification and a personal glucometer for portable, user-friendly, rapid and quantitative readout. Its utility is well demonstrated with the sensitive and specific detection of adenosi...Continue Reading

References

Jun 26, 2003·Nucleic Acids Research·Michael Zuker
Dec 13, 2006·Nature·Mickey UrdeaDeborah C Hay Burgess
Aug 19, 2007·Chembiochem : a European Journal of Chemical Biology·Mehmet Veysel YigitYi Lu
Feb 26, 2008·Journal of the American Chemical Society·Weian ZhaoYingfu Li
Aug 19, 2008·Analytical Chemistry·Jianlong Wang, H Susan Zhou
Apr 22, 2010·Analytical Chemistry·Po-Jung Jimmy Huang, Juewen Liu
May 14, 2011·Advanced Materials·Luc GervaisEmmanuel Delamarche
Mar 9, 2012·Chemical Communications : Chem Comm·Neeshma Dave, Juewen Liu
Apr 4, 2012·ACS Applied Materials & Interfaces·Youssef HelwaJuewen Liu
Jan 24, 2013·Journal of the American Chemical Society·Ling YanChaoyong James Yang
Mar 21, 2013·Chemical Reviews·Weihong TanJianhui Jiang
May 9, 2013·Lab on a Chip·Ali Kemal YetisenChristopher R Lowe
Aug 10, 2013·Journal of the American Chemical Society·Longhua GuoDong-Hwan Kim
Sep 28, 2013·Analytical Chemistry·Karen ScidaRichard M Crooks
Oct 24, 2013·Analytical Chemistry·Deidre SechiNastaran Hashemi
Dec 18, 2013·Biosensors & Bioelectronics·Jie HuFeng Xu
Feb 12, 2014·Lab on a Chip·Marta NovellFrancisco J Andrade
Apr 22, 2014·Chemical Reviews·Onur TokelUtkan Demirci
May 17, 2014·Lab on a Chip·L I Segerink, J C T Eijkel
Nov 7, 2014·Analytical Chemistry·David M CateCharles S Henry
Apr 14, 2015·Angewandte Chemie·Kentaro YamadaDaniel Citterio
Jul 15, 2015·Biosensors & Bioelectronics·Cloé DesmetBastien Doumèche
Aug 11, 2015·Analytical Chemistry·Xiang LiRichard M Crooks
Sep 28, 2015·Biosensors & Bioelectronics·Snober AhmedAbdennour Abbas
Oct 20, 2015·ACS Applied Materials & Interfaces·Kaiqing WuXianrang Song
Dec 20, 2015·Biosensors & Bioelectronics·Yun ZhangJianping Li
Feb 24, 2016·The Analyst·Nathan A MeredithCharles S Henry

❮ Previous
Next ❯

Citations

Nov 3, 2017·The Analyst·Sean K Dembowski, Michael T Bowser
Aug 2, 2018·Advanced Materials·Yan ZhangHong Liu
Nov 15, 2018·Micromachines·Donny Nugraha MazaafriantoManabu Tokeshi
May 1, 2019·Advanced Biosystems·Lewis A FraserJulian A Tanner
Aug 26, 2021·Analytical and Bioanalytical Chemistry·Florence Anne CastelliChristophe Junot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.