USP11, Deubiquitinating Enzyme, Associated with Neuronal Apoptosis Following Intracerebral Hemorrhage

Journal of Molecular Neuroscience : MN
Zhiwei XuDongmei Zhang

Abstract

Protein ubiquitination is a dynamic two-way process that can be reversed or regulated by deubiquitinating enzymes (DUB). USP11, located on the X chromosome, 6 is a member of USP subclass of the DUB family. Here, we demonstrate that USP11 may be involved in neuronal apoptosis in the processes of intracerebral hemorrhage (ICH). From the results of Western blot, immunohistochemistry, and immunofluorescence, we obtained a significant up-regulation of USP11 in neurons adjacent to the hematoma following ICH. Increasing USP11 level was found to be accompanied by the up-regulation of active caspase-3, Fas receptor (Fas), Fas ligand (FasL), and active caspase-8. Besides, USP11 co-localized well with active caspase-3 in neurons, indicating its potential role in neuronal apoptosis. What is more, knocking down USP11 by RNA-interference in PC12 cells reduced active caspase-3 expression. Thus, USP11 may play a role in promoting the brain secondary damage following ICH.

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Citations

Apr 15, 2016·Digestive Diseases and Sciences·Guijuan ZongXudong Chen
Nov 13, 2019·Digestive Diseases and Sciences·Guijuan ZongXudong Chen
Apr 19, 2018·Proceedings of the National Academy of Sciences of the United States of America·Tanggang DengMao Ye
May 1, 2021·International Journal of Molecular Sciences·Choong-Sil LeeJaewhan Song
Jun 19, 2021·Molecular Therapy. Methods & Clinical Development·Xiuqing ZhangXiaoliu Dong

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