USP18 promotes breast cancer growth by upregulating EGFR and activating the AKT/Skp2 pathway

International Journal of Oncology
Yawen TanHaidong Gao

Abstract

Recent studies have suggested that ubiquitin-specific peptidase (USP)18 may act as an oncogene in various types of cancer. Although the role of USP18 in breast cancer cell lines has been elucidated, the underlying mechanisms and clinical role of USP18 in breast cancer are currently not well understood. The bioinformatics analysis and experimental results of the present study demonstrated that aberrant promoter methylation led to increased expression of USP18 in breast cancer. In addition, correlation analysis suggested that a negative correlation between methylation and USP18 mRNA expression was observed in The Cancer Genome Atlas database. USP18 promoted cell proliferation, colony formation and cell cycle progression in vitro. Furthermore, the Gene Set Enrichment Analysis results demonstrated that USP18 may be negatively associated with apoptosis in patients with breast cancer. Bioinformatics analysis results indicated that USP18 was also revealed to be associated with the protein kinase B (AKT) signaling pathway and mammary tumorigenesis in vivo. In addition, the results indicated that USP18 may promote the epidermal growth factor (EGF)-mediated EGF receptor (EGFR)/AKT/S‑phase kinase-associated protein 2 (Skp2) pathway by upr...Continue Reading

References

Jan 15, 2002·The Journal of Biological Chemistry·Michael P MalakhovDong-Er Zhang
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 21, 2002·The Journal of Biological Chemistry·Oxana MalakhovaDong-Er Zhang
Sep 5, 2002·Genes & Development·Kenneth J RitchieDong-Er Zhang
Nov 9, 2004·Nature Medicine·Kenneth J RitchieDong-Er Zhang
Jan 23, 2009·Molecular Biology of the Cell·Jason E Duex, Alexander Sorkin
Feb 4, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jer-Yen Yang, Mien-Chie Hung
Jul 25, 2009·Nature Reviews. Molecular Cell Biology·David KomanderSylvie Urbé
May 20, 2011·The Journal of Biological Chemistry·Jason E DuexBenjamin Kefas
Aug 23, 2011·Apoptosis : an International Journal on Programmed Cell Death·Andrea SgorbissaClaudio Brancolini
Sep 24, 2011·Nature Reviews. Cancer·Stephen B Baylin, Peter A Jones
Jul 4, 2012·Molecular Cancer Therapeutics·Yongli GuoEthan Dmitrovsky
Jan 8, 2013·Experimental Cell Research·Mohammad Shahidul MakkiVicki Huff
May 25, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S MalhotraM Comabella
Oct 12, 2013·CA: a Cancer Journal for Clinicians·Carol DeSantisAhmedin Jemal
Jan 9, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jan 30, 2016·Nature Communications·Andrew E TeschendorffMartin Widschwendter
Dec 16, 2016·Nature·Kathryn L HarperJulio A Aguirre-Ghiso
Dec 20, 2017·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Prashanth RajaramPoorva Mansabdar
Dec 29, 2017·Advances in Experimental Medicine and Biology·Zijie Cai, Qiang Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.