Usutu Virus Isolated from Rodents in Senegal

Viruses
Moussa Moïse DiagneAmadou A Sall

Abstract

Usutu virus (USUV) is a Culex-associated mosquito-borne flavivirus of the Flaviviridae family. Since its discovery in 1959, the virus has been isolated from birds, arthropods and humans in Europe and Africa. An increasing number of Usutu virus infections in humans with neurological presentations have been reported. Recently, the virus has been detected in bats and horses, which deviates from the currently proposed enzootic cycle of USUV involving several different avian and mosquito species. Despite this increasing number of viral detections in different mammalian hosts, the existence of a non-avian reservoir remains unresolved. In Kedougou, a tropical region in the southeast corner of Senegal, Usutu virus was detected, isolated and sequenced from five asymptomatic small mammals: Two different rodent species and a single species of shrew. Additional molecular characterization and in vivo growth dynamics showed that these rodents/shrew-derived viruses are closely related to the reference strain (accession number: AF013412) and are as pathogenic as other characterized strains associated with neurological invasions in human. This is the first evidence of Usutu virus isolation from rodents or shrews. Our findings emphasize the need...Continue Reading

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Citations

Apr 24, 2020·PLoS Neglected Tropical Diseases·Marion CléYannick Simonin
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Mar 27, 2021·Emerging Microbes & Infections·Sarah C KuchinskyNisha K Duggal
Oct 5, 2020·Virology·Amelie Karin Josephine SchoenenwaldTim Skern

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Datasets Mentioned

BETA
AF013412
AY453411
KC754955

Methods Mentioned

BETA
PCR

Software Mentioned

Geneious
Muscle
Chimaera
MaxChi
SiScan
Se
FastTree
GeneConv
Al
BootScan

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