PMID: 15381909Sep 24, 2004Paper

Uterine artery embolization of leiomyomas with trisacryl gelatin microspheres (TGM): pathologic features and comparison with polyvinyl alcohol emboli

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Andres G Chiesa, William R Hart

Abstract

In recent years, uterine artery embolization (UAE) has gained popularity as an alternative to surgery for the treatment of symptomatic uterine leiomyomas. Polyvinyl alcohol (PVA) particles have been the principal agent used for UAE. Recently, trisacryl gelatin microspheres (TGM) have been advocated as a preferable occlusive material for UAE. It is the first embolic agent to be cleared specifically by the United States Food and Drug Administration for this use. To date, information on the tissue effects, distribution, and morphology of UAE with TGM in resected human organs is very limited. Herein, we document the pathologic findings in a 46-year-old woman who underwent hysterectomy and bilateral salpingo-oophorectomy and omentectomy for metastatic colonic adenocarcinoma 19 months after UAE with TGM (microsphere size = 500-700 micron) for uterine leiomyomas. Histologically, a submucosal leiomyoma and an intramural uterine leiomyoma showed massive coagulative necrosis of the infarct-type with a peripheral zone of hyalinized fibrous tissue. Aggregates of TGM were within the necrotic leiomyomas and throughout the myometrium. Non-targeted extrauterine sites also contained TGM, including the paracervical soft tissue and the mesosalpin...Continue Reading

References

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Citations

Mar 20, 2010·Cardiovascular and Interventional Radiology·Alexandre LaurentJean-Pierre Pelage
Nov 1, 2005·Current Opinion in Obstetrics & Gynecology·James B SpiesAmy M White
Jun 17, 2005·The American Journal of Surgical Pathology·Wilko WeichertThomas J Kroencke
Apr 22, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Zahra MalekiRussell Vang
Oct 1, 2008·Journal of Vascular and Interventional Radiology : JVIR·José I BilbaoBruno Sangro
Mar 7, 2008·Fertility and Sterility·Alexandre LaurentJean-Pierre Pelage
Jan 15, 2008·Journal of Vascular and Interventional Radiology : JVIR·Pasteur RasuliElaine E Jolly
May 29, 2007·Fertility and Sterility·Alexandre LaurentJacques Martal
Feb 14, 2007·Journal of Vascular and Interventional Radiology : JVIR·Hyun S KimRussell Vang
Sep 9, 2006·Pathology, Research and Practice·Pavel DundrDaniel Tvrdík
Dec 3, 2014·International Journal of Pharmaceutics·Chris OerlemansJ Frank W Nijsen
Dec 1, 2010·Einstein·Marcos de Lorenzo MessinaEdmund Chada Baracat

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