Uterine choriocarcinoma accompanied by an extremely high human chorionic gonadotropin level and thyrotoxicosis

The Journal of Obstetrics and Gynaecology Research
Tsung-Ying HsiehSoon-Cen Huang

Abstract

The conventional treatments given to a 24-year-old woman with metastatic uterine choriocarcinoma and clinical and biochemical thyrotoxicosis did not appear to have any effect, probably due to an extremely high serum human chorionic gonadotropin (hCG) level which was up to 11,910,000 mIU/mL, and were initially underscored in light of the 'high-dose hook effect'. To our knowledge, no extremely high hCG level in a uterine choriocarcinoma patient has been reported in the literature. Her decapacitating symptoms subsided after the first course of chemotherapy by etoposide, methotrexate, and actinomycin D-cyclophosphamide and vincristine (EMA-CO) regimen. The serum hCG level, which reflects the quantification of host tumor burden, returned to the reference range after the fifth course of chemotherapy and the thyroid function reached euthyroid status before the third course of chemotherapy; two final courses were administered after the hCG level became undetectable. Two years after remission of disease, the patient experienced a normal pregnancy, and a term baby girl was delivered vaginally. No recurrence of uterine choriocarcinoma has been noted for 7 years.

References

Mar 1, 1978·Clinics in Endocrinology and Metabolism·D S CooperF Maloof
Aug 9, 1979·The New England Journal of Medicine·J L Vaitukaitis
Jul 1, 1979·Cancer·N R AndersonK R Falchuk
Mar 1, 1978·Clinics in Endocrinology and Metabolism·H P Higgins, J M Hershman
Apr 1, 1970·The Journal of Clinical Endocrinology and Metabolism·J D Cohen, R D Utiger
Jan 28, 1971·Annals of the New York Academy of Sciences·W B OberE B Price
Sep 1, 1981·British Journal of Obstetrics and Gynaecology·W P SoutterR W Green-Thompson
Oct 1, 1981·Clinical Endocrinology·R J NormanS M Joubert
Oct 1, 1995·Thyroid : Official Journal of the American Thyroid Association·M Yoshimura, J M Hershman
May 1, 1961·The Medical Clinics of North America·W P MYERS
Jul 1, 1963·The Journal of Clinical Endocrinology and Metabolism·W D ODELLR HERTZ
May 26, 2004·Best Practice & Research. Clinical Endocrinology & Metabolism·Jerome M Hershman

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Citations

Jul 1, 2009·Expert Opinion on Medical Diagnostics·Tsui-Lien Mao, Ie-Ming Shih
Feb 22, 2012·The American Journal of Medicine·Chiu-ming NgSau-cheung Tiu
Jul 22, 2009·Journal of Proteomics·Glen L Hortin, Denis Sviridov
Sep 28, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Bettina Chale-MatsauTahir S Pillay

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