PMID: 108397Mar 1, 1979

Uterine contractility and plasma levels of steroid hormones after intravaginal treatment of pregnant Japanese monkeys (Macaca fuscata fuscata) with 16,16-dimethyl-trans-delta2-prostaglandin E-1 methyl ester

Journal of Reproduction and Fertility
K OshimaM Hayashi


Intravaginal treatment with a PGE-1 analogue (ONO-802) resulted in strong uterine contractions with a high frequency which lasted for more than 3 h. When 20-50 microgram ONO-802/kg were administered intravaginally 5 times every 3 h in 5 pregnant animals, vaginal bleeding started by 6 h and abortion occurred by 26 h after the initial treatment. There were no significant side effects. Plasma levels of steroid hormones, especially progesterone and 20alpha-dihydroprogesterone, fluctuated initially and then finally dropped to undetectable levels within 24 h.


Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia
Jan 1, 1984·Teratogenesis, Carcinogenesis, and Mutagenesis·J A PetrereF A de la Iglesia

Related Concepts

Abortion Failure
Estradiol, (16 alpha,17 beta)-Isomer
Progesterone, (9 beta,10 alpha)-Isomer
Prostaglandins E, Synthetic
Gonadal Steroid Hormones
Uterine Contraction

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