Uterine contractility in response to different prostaglandins: results from extracorporeally perfused non-pregnant swine uteri

Human Reproduction
A MuellerR Dittrich

Abstract

Prostaglandins (PGs) are important stimulators of uterine contractility. Limited data are available at present on the effects of different PGs on uterine contractility, measured using intraluminal pressure changes in the complete uterus. The goal of this study was to assess dynamic changes in uterine contractility and peristalsis in response to PGs in comparison with the effects of oxytocin administration. An extracorporeal perfusion model of swine uteri was used, which keeps the uterus in a functional condition, and is appropriate for the study of physiological questions. Oxytocin- and PG-induced uterine contractility and peristalsis were assessed using an intrauterine double-chip microcatheter. A dose-dependent increase in intrauterine pressure (IUP) in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was observed after the administration of PGF(2alpha) and oxytocin, which reached a plateau after further stimulation. A dose-dependent increase in IUP in the isthmus uteri (P < 0.001) and the corpus uteri (P < 0.001) was also observed after the administration of PGE(1) and PGE(2), with a plateau in IUP in the middle-concentration range and a decrease in the course of further stimulation. PGE(2) caused significantly...Continue Reading

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Citations

Jun 1, 2012·Archives of Gynecology and Obstetrics·Yong-Il ShinByung-Cheul Shin
Apr 24, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Julian KuenzelRalf Dittrich
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Nov 11, 2008·Reproduction in Domestic Animals = Zuchthygiene·R DittrichT Maltaris
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Apr 28, 2012·Reproductive Sciences·Mrinalini BalkiJose C A Carvalho
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Dec 5, 2020·Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere·Sarah BlimHartwig Bostedt
Jul 22, 2019·Best Practice & Research. Clinical Obstetrics & Gynaecology·Thomas Drew, Mrinalini Balki

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