Uterine Endometrial Stromal Tumors With Limited Infiltration: First Report of a Case Series Indicating Potential for Malignant Behavior

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Michelle Moore, W Glenn McCluggage

Abstract

The distinction between a uterine endometrial stromal nodule (ESN) and low-grade endometrial stromal sarcoma (LGESS) is based on the nature of the interface between the lesion and the surrounding myometrium and the presence or absence of vascular invasion. Most LGESS exhibit widespread irregular myometrial invasion with or without vascular invasion, whereas ESNs are well-circumscribed without vascular invasion. Tavassoli and Norris proposed that minor marginal irregularity (up to 3 protrusions, each <3 mm beyond the main mass) is allowable in an ESN and these criteria have been incorporated into the World Health Organization Classification. There is a small group of neoplasms with marginal irregularity greater than that allowable in ESN but without the widespread myometrial infiltration typical of most LGESS. Such neoplasms have been categorized as endometrial stromal tumor with limited infiltration but there have been no studies which have provided follow-up in this group of neoplasms. We aimed to determine the clinical behavior of this uncommon group of neoplasms. From a series of 19 endometrial stromal tumors with limited infiltration, mainly from consultation practice, we obtained follow-up information in 16 cases by contac...Continue Reading

References

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Oct 25, 2013·International Journal of Surgical Pathology·Ting-Fu SuShin Nieh

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Citations

Jul 18, 2020·Genes, Chromosomes & Cancer·Anjelica HodgsonGulisa Turashvili
Apr 4, 2021·Diagnostics·Iolia AkaevSiavash Rahimi
Mar 16, 2021·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Cécile Le PageKurosh Rahimi

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