Uterine environment and breed effects on erythropoiesis and liver protein secretion in late embryonic and early fetal swine

Biology of Reproduction
P L PearsonJ L Vallet

Abstract

In this study we investigated erythropoiesis and fetal liver protein secretion during late embryonic (Day 24 and Day 30) and early fetal (Day 40) development in pigs from domestic white crossbred (WC) gilts with a normal (intact; INT) or crowded (unilateral hysterectomized/ovariectomized; UHO) uterine environment, or from prolific Chinese Meishan (MS) gilts. Increased fetal weight, fetal liver weight, placental weight, total red blood cells, hematocrit, blood hemoglobin content, and maternal plasma erythropoietin (EPO) levels were observed as gestation advanced. Cultured fetal liver secretion of transferrin and a protein of Mr 12500 and pI 7.5 also increased as gestation advanced. Fetal plasma EPO declined between Day 30 and Day 40. Differential counts of circulating erythroid precursors revealed a decline in basophilic erythroblasts and polychromatic erythroblasts between Day 24 and Day 40, an increase in orthochromatic erythroblasts on Day 30 followed by a drop on Day 40, and an increase in the percentage of reticulocytes/ erythrocytes from < 1.0% to approximately 90% of circulating red blood cells between Day 24 and Day 40. Differences among the treatment groups included a lower fetal survival percentage in UHO (vs. INT or M...Continue Reading

Citations

May 10, 2001·Animal Reproduction Science·H G KlemckeP L Pearson
Aug 30, 2000·Domestic Animal Endocrinology·P L PearsonJ L Vallet
Aug 7, 2003·The Veterinary Journal·Chris E HostetlerMark A Mirando
Apr 18, 2002·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·R B DavidI Harbitz
Sep 5, 2002·The British Journal of Nutrition·Frédéric GuayJean-Paul Laforest
Sep 29, 2011·Animal Science Journal = Nihon Chikusan Gakkaihō·Longchao ZhangLixian Wang
Apr 14, 2005·Journal of Animal Science·H MesaW R Lamberson

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