Uterine evacuation by vaginal misoprostol after second trimester pregnancy interruption

Acta Obstetricia Et Gynecologica Scandinavica
A BugalhoS Bergström

Abstract

The purpose was to study the capacity of vaginal misoprostol in combination with methylergometrine to achieve complete evacuation of the uterus without ensuing surgical evacuation of the uterine cavity. We performed this trial on 228 women seeking pregnancy interruption. Vaginal misoprostol was given in a dosage of 800 micrograms in early second trimester. All women received concomitant treatment with peroral methlyergometrine from the moment of misoprostol application every 8 hours until uterine evacuation. Follow-up was continued until the first menstruation after interruption. Complete uterine evacuation was achieved in 173/228 cases (76%) [group 1]. The remaining 55 women [group 2] underwent manual evacuation of placental remnants trapped in the cervix. In seven of these women a conventional curettage was carried out due either to ultrasound evidence of placental remnants or due to uterine bleeding. The interval between misoprostol application and fetal expulsion averaged 14.9 hours (s.d. 9.6) in group 1 and 21.0 hours (s.d. 14.5) in group 2 (p=0.006). Misoprostol, in combination with methylergometrine, is a remarkably efficient drug in achieving uterine evacuation also in the absence of surgical evacuation of the uterine c...Continue Reading

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Citations

Apr 9, 2001·Contraception·J A GonzalezM W Alverson
Mar 24, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Y Herabutya, P O-Prasertsawat
Jan 9, 2003·Obstetrics and Gynecology·Apichart ChittacharoenPiyaporn Punyavachira
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Jun 15, 1999·The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception·J L CarbonellC Sánchez
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Oct 4, 2003·American Journal of Obstetrics and Gynecology·Deborah M FeldmanWinston A Campbell
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Jul 11, 2001·Tropical Doctor·J Munthali, J Moodley

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