Uterine gestational choriocarcinoma developing after a long latent period in a postmenopausal woman: the value of DNA polymorphism studies

International Journal of Surgical Pathology
Ciaran J O'NeillW Glenn McCluggage

Abstract

This article reports a uterine gestational choriocarcinoma arising in a 57-year-old woman with a long latent period of 22 years from the last known pregnancy. Diagnosis was made on an endometrial biopsy specimen, and given the age of the patient, the long latent period, and the limited sample, trophoblastic differentiation within an endometrial carcinoma was considered. The results of DNA polymorphism studies illustrated both paternal and maternal alleles within the tumor in equal amounts, confirming the neoplasm to be gestational in origin and to have originated from a nonmolar gestation. The report discusses the value of DNA polymorphism studies in distinguishing gestational from nongestational choriocarcinoma and from trophoblastic differentiation within a carcinoma.

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Citations

Oct 16, 2014·Journal of Mid-life Health·Sunil K SamalSeetesh Ghose
Mar 17, 2016·Human Pathology·John Aranake-ChrisingerJohn D Pfeifer
Aug 4, 2009·Placenta·J ZhaoX Y Yang
Jan 1, 2011·Gynecologic Oncology Case Reports·Wen-Fang ChengChi-An Chen
Nov 27, 2010·Journal of Medical Case Reports·Nisarg R DesaiQun Dai
Sep 7, 2017·The American Journal of Surgical Pathology·Johanna SavageBrigitte M Ronnett
Aug 24, 2011·Korean journal of urology·Tahir KaradenizCağlar Cakır
Jun 6, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Kojo R RawishOluwole Fadare
Apr 28, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natalia BuzaPei Hui
Nov 23, 2012·International Journal of Surgical Pathology·Ildikó VereczkeyErika Tóth
Aug 20, 2019·Diagnostic Pathology·Xiaofei ZhangXing Xie
Jun 2, 2012·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Yukihiro HirataTadao Tanaka
Jun 6, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natalia Buza, Pei Hui

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