Uterine leiomyoma: available medical treatments and new possible therapeutic options

The Journal of Clinical Endocrinology and Metabolism
Md Soriful IslamPasquapina Ciarmela

Abstract

Uterine leiomyomas (fibroids or myomas) are benign tumors of the uterus and are clinically apparent in up to 25% of reproductive-age women. Heavy or abnormal uterine bleeding, pelvic pain or pressure, infertility, and recurrent pregnancy loss are generally associated with leiomyoma. Although surgical and radiological therapies are frequently used for the management of this tumor, medical therapies are considered the first-line treatment of leiomyoma. A review was conducted of electronic and print data comprising both original and review articles on pathophysiology and medical treatments of uterine leiomyoma retrieved from the PubMed or Google Scholar database up to June 2012. These resources were integrated with the authors' knowledge of the field. To date, several pathogenetic factors such as genetic factors, epigenetic factors, estrogens, progesterone, growth factors, cytokines, chemokines, and extracellular matrix components have been implicated in leiomyoma development and growth. On the basis of current hypotheses, several medical therapies have been investigated. GnRH agonist has been approved by US Food and Drug Administration for reducing fibroid volume and related symptoms. In addition, the FDA also approved an intraut...Continue Reading

References

May 1, 1991·Cancer Genetics and Cytogenetics·M Kiechle-SchwarzA A Sandberg
Oct 1, 1990·American Journal of Clinical Pathology·S F Cramer, A Patel
Jan 1, 1985·International Archives of Allergy and Applied Immunology·A KodaM Nakazawa
Oct 1, 1981·Fertility and Sterility·V C Buttram, R C Reiter
Oct 1, 1994·Journal of Biochemistry·H YamadaS R Pinnell
Mar 24, 1995·Science·A Levitzki, A Gazit
Jan 1, 1994·Annual Review of Medicine·P M Conn, W F Crowley
Jun 1, 1996·Clinical Obstetrics and Gynecology·A J MoralesA A Murphy
Jan 1, 1997·Annual Review of Medicine·F CadepondE E Baulieu
May 1, 1997·Proceedings of the Society for Experimental Biology and Medicine·H Boettger-TongG M Stancel
Dec 16, 1997·Obstetrics and Gynecology·L M MarshallD J Hunter
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·B S LeeRomana A Nowak
Jan 8, 1999·Molecular and Cellular Biochemistry·M WolańskaE Bańkowski
Aug 24, 1999·Pharmacology & Therapeutics·A Levitzki
Feb 24, 2001·Lancet·E A Stewart
Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dirk Wildemeersch, E Schacht
Jun 18, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Young-Joon Surh
Jun 18, 2002·Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi·Makoto HiroiTakayuki Aimoto
Oct 5, 2002·The Journal of Clinical Endocrinology and Metabolism·Stefano PalombaFulvio Zullo
Oct 24, 2002·Cancer Genetics and Cytogenetics·Azra H LigonCynthia C Morton
May 22, 2003·The American Journal of Pathology·Holly R MasonJohn J Castellot
Jun 12, 2003·Fertility and Sterility·Paolo VercelliniPier Giorgio Crosignani
Jun 27, 2003·Environmental Health Perspectives·Gordon P FlakeDarlene Dixon
Dec 11, 2003·Molecular Human Reproduction·G BifulcoC Nappi
Dec 12, 2003·Steroids·Erin E Gainer, André Ulmann
Jun 19, 2004·Human Reproduction·Asher ShushanHannah Ben-Bassat
Oct 8, 2004·American Journal of Physiology. Cell Physiology·Byoung Ywong KimJae Hoon Bae

Citations

Oct 30, 2013·Forensic Science, Medicine, and Pathology·Iwao HasegawaKlaus Püschel
Apr 3, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Johannes OttKatharina Walch
Jul 1, 2014·Maturitas·Faustino R Pérez-LópezMargaret Rees
Dec 9, 2014·Women's Health·Kristin Van Heertum, Larry Barmat
Sep 11, 2014·Human Reproduction Update·Molly B MoravekSerdar E Bulun
Aug 7, 2013·Expert Opinion on Pharmacotherapy·Friederike HoellenMichael K Bohlmann
Oct 13, 2015·Current Medical Research and Opinion·Philippe Y LabergePeter M Janiszewski
Nov 5, 2014·Current Medical Research and Opinion·Sukhbir Sony Singh, Liane Belland
Feb 5, 2016·The Journal of Obstetrics and Gynaecology Research·Yang ShenMu-Lan Ren
Feb 4, 2016·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Qi-Wei LiuJian-Jun Wang
Oct 8, 2013·Fertility and Sterility·Qi ShenXueqiong Zhu
Jan 19, 2016·Fertility and Sterility·Amrita PatelWilliam H Catherino
Jan 23, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Banafsheh N KashaniFelice Petraglia
Oct 16, 2015·The Journal of Obstetrics and Gynaecology Research·Yang ShenMu-Lan Ren
Oct 20, 2015·Fertility and Sterility·Jacques DonnezErnest Loumaye
Jan 5, 2016·Best Practice & Research. Clinical Obstetrics & Gynaecology·Fernando M ReisTânia M Ortiga-Carvalho
Nov 29, 2015·Cell and Tissue Research·Olga ProticPasquapina Ciarmela
Nov 4, 2015·Best Practice & Research. Clinical Obstetrics & Gynaecology·Md Soriful IslamPasquapina Ciarmela
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang ShenMu-Lan Ren
May 20, 2014·Maturitas·Pasquapina CiarmelaMario Castellucci
May 20, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yang ShenYun-Lang Cai
May 6, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yang ShenQian Xu
Aug 31, 2014·Fertility and Sterility·Nathalie Chabbert-BuffetPhilippe Bouchard
Sep 23, 2014·Fertility and Sterility·Mathieu LuyckxJacques Donnez
Nov 4, 2015·Archives of Gynecology and Obstetrics·Hans-Joachim AhrendtDolores Foth
Jul 29, 2016·Human Reproduction Update·Jacques Donnez, Marie-Madeleine Dolmans
Sep 7, 2016·Case Reports in Medicine·Elena de la FuenteNuria Abril
Jun 25, 2014·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Malana MosheshDonna Baird
Jun 14, 2017·Critical Reviews in Food Science and Nutrition·Md Soriful IslamPasquapina Ciarmela
Jul 9, 2014·Reproductive Sciences·Pasquapina CiarmelaFelice Petraglia
Nov 18, 2017·International Journal of Molecular Sciences·Michał CiebieraGrzegorz Jakiel
Dec 2, 2017·International Journal of Molecular Sciences·Michał CiebieraGrzegorz Jakiel
Feb 15, 2018·The Journal of Biological Chemistry·Min Ju ParkThomas G Boyer
Dec 1, 2017·Human Reproduction Update·Md Soriful IslamPasquapina Ciarmela
Mar 21, 2015·The Cochrane Database of Systematic Reviews·Rafael M MoroniLuiz Gustavo Brito

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Nodding Syndrome

Nodding Syndrome is a neurological and epileptiform disorder characterized by psychomotor, mental, and growth retardation. Discover the latest research on Nodding Syndrome here.

LRRK2 & Microtubules

Mutations in the LRRK2 gene are risk-factors for developing Parkinson’s disease (PD). LRRK2 mutations in PD have been shown to enhance its association with microtubules. Here is the latest research.

Related Papers

International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics
Changyong FengKevin Fiscella
European Journal of Obstetrics, Gynecology, and Reproductive Biology
Nirmala Duhan, Daya Sirohiwal
© 2021 Meta ULC. All rights reserved