Uterine leiomyoma versus leiomyosarcoma: a new attempt at differential diagnosis based on their cellular characteristics

Histopathology
K Watanabe, T Suzuki

Abstract

To differentiate uterine leiomyoma (LM) with 'pseudosarcomatous' features from leiomyosarcoma (LMS). We hypothesized that because pseudosarcomatous LM is only a benign variant of conventional LM, it may have some characteristics different from LMS. Fourteen uterine smooth muscle tumours, which had been diagnosed as LMS previously, were reviewed and divided into adverse outcome (true LMS; seven cases) and excellent outcome groups (presumed pseudosarcomatous LM; seven cases) based on their clinical course. The tumours of the adverse outcome group were composed of rather uniform long spindle cells similar to those of leiomyosarcoma arising from the soft tissue. All tumours in this group had coagulative necrosis and all but one case were diagnosed preoperatively as malignant. In contrast, the tumours of the excellent outcome group showed significant histological diversity both between tumours and also in the same tumour and areas indistinguishable from conventional LM were often seen. All the tumours of this group were diagnosed preoperatively as benign. Immunohistochemically, all tumours of the excellent outcome group expressed progesterone receptor, often intensely, and also frequently expressed oestrogen receptor. In contrast, a...Continue Reading

References

Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·B P EydenC H Buckley
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·I KonishiS Tojo
Jun 1, 1994·The American Journal of Surgical Pathology·S W BellM R Hendrickson
Jul 1, 1996·The American Journal of Surgical Pathology·G P NielsenR E Scully
Nov 14, 1997·The American Journal of Surgical Pathology·K A Downes, W R Hart
Jan 19, 1999·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Y L ZhaiS Fujii
Oct 31, 2001·Histopathology·N Wilkinson, T P Rollason

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Citations

Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Brian R GannonTimothy J Childs
Nov 1, 2013·Journal of the American Veterinary Medical Association·Kellye S Joiner, Benjamin W Newcomer
Jul 19, 2011·Best Practice & Research. Clinical Obstetrics & Gynaecology·Angiolo Gadducci
May 24, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·L Brown
Jun 7, 2007·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Nil Ustündagğ ComunoğluNil Molinas
Sep 8, 2010·Veterinary Pathology·M R S IlhaB W Rohrbach
Feb 28, 2017·Australian Veterinary Journal·F W YapK L Bowlt-Blacklock
Oct 5, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Tamara Veiga-PargaShelley J Newman
Sep 7, 2007·Virchows Archiv : an International Journal of Pathology·Kazuo WatanabeShu Soeda
Oct 1, 2018·Indian Journal of Thoracic and Cardiovascular Surgery : Official Organ, Association of Thoracic and Cardiovascular Surgeons of India·Marion MauduitBertrand Delatour
Feb 7, 2008·Archives of Pathology & Laboratory Medicine·Michael T Deavers
Jan 8, 2022·International Journal of Surgical Pathology·Murat Çelik, Zeliha Esin Çelik

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