Uterine leiomyosarcoma diffusely express disialoganglioside GD2 and bind the therapeutic immunocytokine 14.18-IL2: implications for immunotherapy

Cancer Immunology, Immunotherapy : CII
Angela J ZiebarthJoseph P Connor

Abstract

Uterine leiomyosarcoma comprises <1 % of uterine malignancies and is known for its clinically aggressive course. Extrapelvic recurrences are common and often lethal. No adjuvant therapies have been shown to significantly improve overall survival, highlighting the need for new and novel therapies. Our objective was to determine whether GD2-specific immunocytokine therapy may be explored for the treatment for uterine leiomyosarcoma. To do so, frozen tissue sections were obtained from the Gynecologic Oncology Group tumor bank and evaluated by immunohistochemistry (IHC) for GD2 expression using both the parent mouse monoclonal antibody 14G2A and immunocytokine 14.18-IL2 generated from the 14G2A sequence. Immunoreactivity was detected by avidin-biotin complex with DAB substrate. Specimens were reviewed by a pathologist with light microscopy and classified as negative, 1+, 2+ or 3+, compared to human melanoma cells as positive control and tissue incubated in the absence of primary antibody as negative control. GD2 was diffusely present in all evaluable samples. 10 tumors (67 %) demonstrated 3+ IHC intensity for GD2, two tumors (13 %) demonstrated 2+ intensity, and 3 (20 %) tumors demonstrated 1+ intensity. Eleven cases had sufficient...Continue Reading

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Citations

May 16, 2015·Current Treatment Options in Oncology·Melissa Burgess, Hussein Tawbi
Apr 19, 2017·Oncotarget·Giulia OrsiMassimo Dominici
Jul 31, 2019·Biomolecules·Sumeyye CavdarliPhilippe Delannoy
Sep 25, 2017·The Oncologist·Michael J NathensonEdward Sausville
Apr 9, 2019·Fetal and Pediatric Pathology·Zeynep AygünNil Comunoglu

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