Uterine Leukocyte Function and Dysfunction: A Hypothesis on the Impact of Endometriosis

American Journal of Reproductive Immunology : AJRI
Kirstin Parkin, Asgerally T Fazleabas

Abstract

Endometriosis is a chronic inflammatory disease characterized by the growth of endometrial glands and stroma outside of the uterus. The disease affects approximately 10-15% of women of reproductive age and presents with clinical symptoms of pelvic pain and infertility. Changes in the leukocyte populations within the ectopic tissue and eutopic endometrium have been reported, and data suggest these alterations contribute to the pathology and symptoms of the disease. In this review, we discussed differences when comparing uterine NK cells and regulatory T cells within the eutopic endometrium between patients with endometriosis and healthy patients, and how these differences relate to implantation failure and/or decreased clearance of menstrual tissue in patients with the disease. The data demonstrate a critical need to examine endometrium and menstrual tissue in patients with endometriosis excluded from studies examining unknown causes of infertility and heavy menstrual bleeding. The information gathered from excluded patients will further enhance our understanding of how the immune system contributes to the pathophysiology of endometriosis and help to identify biomarkers for patients at higher risk for developing endometriosis-as...Continue Reading

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Citations

Mar 2, 2018·American Journal of Reproductive Immunology : AJRI·Hui-Li YangMing-Qing Li
Dec 14, 2017·Molecular Genetics and Genomics : MGG·Aleksandra BylińskaIzabela Nowak
Aug 20, 2019·Human Reproduction Update·Júlia Vallvé-JuanicoLinda C Giudice
Aug 2, 2018·Molecular Medicine Reports·Magdalenia BałkowiecPaweł K Włodarski
Jul 4, 2021·Tissue & Cell·Carlo TicconiAsgerally Fazleabas
Nov 5, 2017·Fertility and Sterility·Stephan GordtsIvo Brosens

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