PMID: 11907942Mar 23, 2002Paper

Uterine surveillance of asymptomatic postmenopausal women taking tamoxifen

Climacteric : the Journal of the International Menopause Society
F J GardnerF al-Azzawi

Abstract

The aim of this study was to assess the ability of transvaginal sonography (TVS) and office hysteroscopy with sharp curettage to characterize the morphological changes in the uteri of asymptomatic postmenopausal women taking long-term tamoxifen for breast cancer. The overall acceptability of a single-visit screening clinic for these women was also evaluated. Fifty-eight women were recruited from patients undergoing regular follow-up at the Leicester Royal Infirmary for breast cancer. A single-visit clinic was acceptable to 94.8% of these women. Transvaginal sonography detected endometrial thickness of greater than 5 mm in 84.5% of cases, but there was no relationship between total tamoxifen exposure and endometrial thickness. Transvaginal sonography also detected uterine lesions such as fibroids and endometrial cysts in 34.5% of cases. Hysteroscopy detected the latter uterine lesions in 53.4% of cases, with three cases (5.2%) of endometrial polyps also being identified in these women. Sharp curettage sampling of the endometrium produced specimens sufficient for diagnosis in 84.5% of cases; 70.7% of specimens were reported as showing types of 'quiescent' endometrium with 13.8% of specimens showing 'active' endometrium. In the la...Continue Reading

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Citations

Aug 5, 2004·Obstetrics and Gynecology·Brian M SlomovitzKaren H Lu
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·T N FayD Hosking
Jun 9, 2009·Current Problems in Surgery·Kristin L CoxV Suzanne Klimberg
Apr 11, 2001·The Journal of Social Psychology·K P Weinfurt, F M Maghaddam
Mar 31, 2010·Multivariate Behavioral Research·John Kammeyer-MuellerAlex Rubenstein
Oct 11, 2015·Personality & Social Psychology Bulletin·Adam HahnCharles M Judd

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