PMID: 1206205Jul 1, 1975Paper

Utero-placental hemodynamics during normal and pathological pregnancies. Its changes under the influence of a beta-sympathicomimetic: salbutamol

Journal de gynécologie, obstétrique et biologie de la reproduction
J P GuikovatyP Dellenbach

Abstract

Utero-placental circulation was studied using a gamma-camera which measures the appearance of a radio-active bolus of transferin tagged with Indium 113 in the region of the placenta and of the myometrium. The technique adopted for the calculations that are carried out allows a ratio between the placental blood flow and the myometrial blood flow to be established. The measurements that were taken in the last trimester of pregnancy showed that there was a significant difference between the ratio in normal pregnancies and in those that resulted in the deliveries of small-for-date babies. The foetus is small-for-date in 80 per cent of cases when the placental blood flow (Dp) to the myometrial blood flow (Dm), ratio is less than 80. It is small-for-dates in 25 per cent of cases if the Dp/Dm is between 0.80 and 1.60. If the Dp/Dm ratio is about 1.60 the foetus is normal in 93 per cent of cases. When we compared especially the variations between the Dp/Dm ratio during the administration of Salbutamol, we showed in the light of work already published that the intravenous administration of 50 mug of Salbutamol brought about a lowering of resistance in the placental blood vessels, and probably an increase in the blood flow at the materna...Continue Reading

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