Uteroglobin and FLRG concentrations in aqueous humor are associated with age in primary open angle glaucoma patients

BMC Ophthalmology
Esther L Ashworth BriggsAnthony L Cook

Abstract

The pathophysiological changes occurring in the trabecular meshwork in primary open angle glaucoma are poorly understood, but are thought to include increased extracellular matrix deposition, trabecular meshwork cell apoptosis, inflammation, trabecular meshwork calcification and altered protein composition of the aqueous humor. Although many proteins are present in aqueous humor, relatively few have been studied extensively, and their potential roles in primary open angle glaucoma are unknown. Analyte concentrations in aqueous humor from 19 primary open angle glaucoma and 18 cataract patients were measured using a multiplex immunoassay. Fisher's exact test was used to assess statistical significance between groups, and correlations of analyte concentrations with age, intraocular pressure, pattern standard deviation, mean deviation, cup-to-disc ratio and disease duration since commencing treatment were tested by Spearman's method. CHI3L1, FLRG, HGF, MIF, P-selectin and Uteroglobin were detected in more than 50% of samples of one or both patient groups, some of which have not previously been quantified in aqueous humor. In the glaucoma but not the cataract group, significant correlations were determined with age for Uteroglobin/S...Continue Reading

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Citations

Nov 18, 2020·Journal of Cachexia, Sarcopenia and Muscle·Joshua R HuotAndrea Bonetto
Jul 3, 2021·Molecular & Cellular Proteomics : MCP·Xiaoyan LiuWei Sun

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Methods Mentioned

BETA
protein assay

Software Mentioned

Prism
Plex Manager
GraphPad
Bio

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