PMID: 6406778May 23, 1983Paper

Uteroplacental dysfunction and prostaglandin metabolism in zinc deficient pregnant rats

Life Sciences
S C CunnaneC F Mills

Abstract

Relationships between perinatal mortality, disrupted utero-placental function and prostaglandin metabolism have been studied in Zn-deficient rats. Uterine contractility in vitro, placental blood flow in vivo, and uterine and placental prostaglandin synthesis from [1-14C] arachidonic acid in vitro were investigated at day 22 of pregnancy. High amplitude uterine contractions were almost completely eliminated and utero-placental blood flow was decreased by 85% by Zn deficiency. Synthesis of [1-14C]-prostaglandin E2, F2 alpha and 6-keto-F1 alpha from [1-14C] arachidonic acid decreased significantly in uterine tissue but increased in placentae. These possibly inter-related effects may contribute to the high perinatal mortality observed in Zn deficiency.

References

Jan 1, 1978·Prostaglandins·M J DuchesneA C de Paulet
Mar 1, 1979·The Journal of Nutrition·W J BettgerB L O'Dell
Feb 15, 1978·American Journal of Obstetrics and Gynecology·M K McLaughlinR A Chez
Jun 1, 1977·American Journal of Obstetrics and Gynecology·R ResnikM H Plumer
Jul 1, 1977·The Journal of Nutrition·B L O'DellP G Reeves
Sep 1, 1967·Canadian Journal of Physiology and Pharmacology·D M Paton, E E Daniel
Nov 22, 1974·Nature·J P Rivers, M A Crawford
Aug 1, 1973·British Journal of Pharmacology·J R Vane, K I Williams
Feb 1, 1972·The Biochemical Journal·A J Sinclair, M A Crawford
Dec 1, 1970·The British Journal of Nutrition·R B Williams, C F Mills
Jul 1, 1968·The American Journal of Physiology·J Apgar
Jan 1, 1981·Progress in Lipid Research·S C CunnaneJ Davignon
May 15, 1980·American Journal of Obstetrics and Gynecology·R Resnik, G W Brink
Mar 1, 1981·The Journal of Clinical Investigation·J G GerberA S Nies
Oct 1, 1980·Prostaglandins·R W Kelly, M H Abel
Jul 1, 1981·American Journal of Surgery·J J RoslynH E Gordon
Jan 1, 1980·The Journal of Nutrition·W J BettgerB L O'Dell
Sep 1, 1980·Proceedings of the Society for Experimental Biology and Medicine·S C Cunnane, D F Horrobin
Jan 15, 1965·American Journal of Obstetrics and Gynecology·A I CSAPO, H TAKEDA

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemical and Biophysical Research Communications
J H Fishman, J Fishman
Biological Trace Element Research
R LaitinenS S Salmela
© 2021 Meta ULC. All rights reserved