Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy.

The Journal of Physiology
Marc Q MazzucaMary E Wlodek

Abstract

Intrauterine growth restriction is a risk factor for cardiovascular disease in adulthood. We have previously shown that intrauterine growth restriction caused by uteroplacental insufficiency programmes uterine vascular dysfunction and increased arterial stiffness in adult female rat offspring. The aim of this study was to investigate vascular adaptations in growth restricted female offspring when they in turn become pregnant. Uteroplacental insufficiency was induced in WKY rats by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) on day 18 of pregnancy. F0 pregnant females delivered naturally at term. F1 Control and Restricted offspring were mated at 4 months of age and studied on day 20 of pregnancy. Age-matched non-pregnant F1 Control and Restricted females were also studied. Wire and pressure myography were used to test endothelial and smooth muscle function, and passive mechanical wall properties, respectively, in uterine, mesenteric, renal and femoral arteries of all four groups. Collagen and elastin fibres were quantified using polarized light microscopy and qRT-PCR. F1 Restricted females were born 10–15% lighter than Controls (P <0.05). Non-pregnant Restricted females had increased uterine and rena...Continue Reading

References

Dec 1, 1992·American Journal of Obstetrics and Gynecology·S T Davidge, M K McLaughlin
Jul 1, 1992·The American Journal of Physiology·K MackeyM K McLaughlin
May 1, 1985·The American Journal of Physiology·K K GriendlingR H Cox
May 1, 1989·The American Journal of Physiology·D J AnnibaleK E Kamm
Feb 1, 1995·Pharmacology & Therapeutics·L PostonJ M Ritter
Sep 1, 1996·American Journal of Obstetrics and Gynecology·M YamasakiJ G Umans
Apr 1, 1997·American Journal of Obstetrics and Gynecology·Y NiG Osol
Jul 1, 1997·The American Journal of Physiology·R E GandleyM K McLaughlin
Oct 10, 1997·The American Journal of Physiology·J St-LouisM Brochu
Jan 12, 1999·British Journal of Pharmacology·A S ZwartR E Widdop
Mar 10, 2000·Seminars in Perinatology·K L ThornburgM J Morton
Dec 1, 2000·Human Reproduction·J J Dalle LuccaN L Alsip
Mar 15, 2001·American Journal of Physiology. Heart and Circulatory Physiology·R R MagnessI M Bird
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·S J WiggH C Parkington
Jan 17, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ian M BirdRonald R Magness
Feb 27, 2003·Biology of Reproduction·Christy-Lynn M Cooke, Sandra T Davidge
Jun 24, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J C GillhamP N Baker
Jan 31, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Leonid LukshaKarolina Kublickiene
Sep 11, 2004·American Journal of Physiology. Heart and Circulatory Physiology·DaLiao Xiao, Lubo Zhang
Jan 22, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mary E WlodekJane M Moseley
Nov 7, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Ninian N LangKarolina Kublickiene
Nov 25, 2006·Nature Clinical Practice. Nephrology·David J P BarkerMark A Hanson
Apr 20, 2007·Journal of the American Society of Nephrology : JASN·Mary E WlodekKaren M Moritz
Dec 14, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rachael O'DowdMary E Wlodek
May 28, 2008·Gender Medicine·Daniela GrigoreBarbara T Alexander
Sep 27, 2008·The Journal of Physiology·Paul M Vanhoutte, Eva H C Tang
Feb 7, 2009·Physiology·George Osol, Maurizio Mandala
Feb 17, 2009·The Journal of Physiology·Gordon B Drummond
Feb 19, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robin E GandleyJulie A DeLoia
Apr 13, 2010·Pflügers Archiv : European journal of physiology·Gillian EdwardsArthur H Weston
Oct 7, 2010·Cardiovascular & Hematological Agents in Medicinal Chemistry·Ossama M Reslan, Raouf A Khalil
Jan 29, 2011·The Journal of Obstetrics and Gynaecology Research·Yuka MushaSatoru Takeda

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Citations

Apr 16, 2013·Clinical and Experimental Pharmacology & Physiology·Linda A GalloMary E Wlodek
Mar 26, 2016·Frontiers in Physiology·Amanda N Sferruzzi-Perri, Emily J Camm
Sep 10, 2014·Clinical and Experimental Pharmacology & Physiology·Jordanna S MasterMary J Black
Sep 9, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·S B CorvinoD C Damasceno
Oct 1, 2016·Journal of Developmental Origins of Health and Disease·H DickinsonJ L Morrison
Mar 13, 2014·American Journal of Physiology. Endocrinology and Metabolism·Kathryn L GatfordGlenn K McConell
Sep 17, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Maria JelinicLaura J Parry
Feb 14, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Melanie TranMary E Wlodek
Sep 18, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M Jane BlackKate M Denton
Jun 23, 2019·BMC Pregnancy and Childbirth·Alexandra D GeorgeDonna T Geddes
Aug 6, 2013·Reproduction, Fertility, and Development·Linda A GalloMary E Wlodek
Dec 17, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dayana MahizirMary E Wlodek
Aug 28, 2021·International Journal of Molecular Sciences·Xiangqun Hu, Lubo Zhang

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