Utility of a Hybrid IVIM-DKI Model to Predict the Development of Distant Metastasis in Head and Neck Squamous Cell Carcinoma Patients

Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine
Noriyuki FujimaHiroki Shirato

Abstract

To evaluate the diagnostic power of hybrid intravoxel incoherent motion (IVIM)-diffusion kurtosis imaging (DKI) model parameters in pretreatment for the prediction of future distant metastasis in head and neck squamous cell carcinoma (HNSCC) patients. We retrospectively evaluated 49 HNSCC patients who underwent curative chemoradiation therapy. Diffusion-weighted image (DWI) acquired by single-shot spin-echo echo-planar imaging with 12 b-values (0-2000) was performed in all patients before any treatment. We calculated the IVIM-DKI parameters and the conventional apparent diffusion coefficient (ADC) in the ROI placed on the primary lesion. The presence of future distant metastasis was determined by histological findings or clinical follow-up. A univariate analysis revealed significant differences between the patients with distant metastasis and those without in slow diffusion coefficient (D) and kurtosis value (K). Highest diagnostic accuracy was obtained by the D value. In addition, a multivariate analysis revealed that the D value was an independent predictor of future distant metastasis. The D and K values obtained by this hybrid IVIM-DKI model can be one of the diagnostic tools for the prediction of future distant metastasis ...Continue Reading

References

Jul 29, 2003·Head & Neck·Majid O F Al-OthmanWilliam M Mendenhall
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jens H JensenKyle Kaczynski
Oct 16, 2010·Head & Neck·Benjamin LallemantJean-Paul Brouillet
Sep 3, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Xiao Quan XuJeong Hyun Lee

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Citations

Dec 19, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrada IanuşNoam Shemesh
Jun 17, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Mami Iima
Sep 2, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nienke D SijtsemaJuan A Hernandez-Tamames
Jan 24, 2020·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Minghui SongQueenie Chan

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Methods Mentioned

BETA
imaging technique
biopsy

Software Mentioned

SPSS
IVIM

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