Utility of CD117 immunoreactivity in differentiating metastatic melanoma from clear cell sarcoma.

Archives of Pathology & Laboratory Medicine
Joaquin J GarciaAndrew E Horvai

Abstract

Clear cell sarcoma is a malignant soft tissue tumor with melanocytic differentiation. Molecular methods are sometimes necessary to identify the unique t(12; 22)(q13;q12) translocation and differentiate clear cell sarcoma from melanoma. To determine whether CD117 immunoreactivity may be useful in separating melanoma from clear cell sarcoma. We identified 20 tumors listed in our surgical pathology files that were diagnosed as clear cell sarcoma or in which clear cell sarcoma was strongly considered. These were tested for the presence of the t(12;22) translocation by reverse transcriptase/polymerase chain reaction and sequencing from paraffin-embedded tissue. Tumors with a t(12;22) translocation were immunostained with an antibody to CD117 and compared with 16 similarly stained metastatic melanomas. Twelve tumors from 9 patients demonstrated t(12;22). No metastatic melanomas demonstrated t(12;22). None of the 12 clear cell sarcomas showed membrane or cytoplasmic staining for CD117. Conversely, 10 (63%) of 16 metastatic melanomas were, at least focally, positive for CD117; this difference was significant (P < .001). Interestingly, 3 tumors in which clear cell sarcoma was initially considered as a diagnosis, but which lacked t(12;22...Continue Reading

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Citations

Nov 16, 2011·International Journal of Surgical Pathology·Patrick ShenjereSaumitra S Banerjee
Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Josefine Heim-Hall, Sophia L Yohe
Aug 8, 2008·Archives of Pathology & Laboratory Medicine·Mehmet L GulerElizabeth A Montgomery
Apr 19, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joaquin J GarciaAndrew E Horvai
Jul 20, 2007·Virchows Archiv : an International Journal of Pathology·Camilla E CominLuca Messerini
Feb 28, 2008·The American Journal of Surgical Pathology·Masanori HisaokaHiroshi Hashimoto
Mar 11, 2009·Journal of Korean Neurosurgical Society·Dae-Hyun KimYoung-Dae Cho
Jun 9, 2009·The Journal of Dermatology·Yasutoshi HidaSeiji Arase

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