Utility of CD26 in flow cytometric immunophenotyping of T-cell lymphomas in tissue and body fluid specimens

Cytometry. Part B, Clinical Cytometry
Diane M PiersonJeffrey L Jorgensen

Abstract

CD26 is expressed by most CD4+ T cells in normal peripheral blood specimens. Neoplastic T cells are frequently CD26- in mycosis fungoides/Sezary syndrome involving the peripheral blood. However, CD26 expression by reactive and neoplastic T cells in solid tissues and body fluids has not been fully characterized by flow cytometry (FC). Solid tissue and body fluid specimens were assayed for CD26 expression using four-color FC immunophenotyping, by qualitative assessment of population clusters, and by quantitation with comparison with isotype controls. Benign T cells were studied in reactive tissues and in the background of other malignancies. Many T-cell lymphomas were dim or negative for CD26, whereas a few were brightly positive. In the majority of T-cell lymphomas, CD26 expression could potentially help identify aberrant population clusters. T cells in reactive tissue specimens and tumor-infiltrating T cells were commonly dim to negative for CD26. Both T-cell lymphomas and reactive T cells in tissue and body fluid specimens often show low levels of CD26 expression. Therefore, quantitative methods may not reliably distinguish benign from neoplastic T cells in these specimens. However, CD26, in combination with other T-cell marke...Continue Reading

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Citations

Nov 15, 2011·The Journal of Clinical Investigation·Clara Curiel-LewandrowskiWilliam W Cruikshank
Sep 23, 2010·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Howard J Meyerson
Nov 27, 2015·American Journal of Hematology·Ryan A Wilcox
Oct 13, 2011·American Journal of Hematology·Ryan A Wilcox
Jul 22, 2014·American Journal of Hematology·Ryan A Wilcox
Nov 9, 2016·Disease Markers·Alexandra IonDaniel Boda
Nov 1, 2016·Expert Review of Hematology·Agnieszka KorfelMichael Glantz
Nov 19, 2011·American Journal of Clinical Pathology·Alexandra C HristovMichael J Borowitz
Jan 23, 2020·The Australasian Journal of Dermatology·Kah Wai CheongJoel Hua-Liang Lim
May 3, 2019·Cytometry. Part B, Clinical Cytometry·Elsa MaitreXavier Troussard
Feb 12, 2021·Frontiers in Immunology·Jamal Hussen, Hans-Joachim Schuberth

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