PMID: 6110697Feb 1, 1981Paper

Utility of chloranil in assay of naphazoline, clemizole, penicillin G sodium, and piperazine

Journal of Pharmaceutical Sciences
S BelalH Abdine

Abstract

A simple and sensitive spectrophotometric method is described for the assay of naphazoline, clemizole, penicillin G sodium, and piperazine. The method was based on the formation of a charge transfer complex between these drugs as n-donors and chloranil, the pi-acceptor. Conformity to Beer's law enabled the assay of dosage forms of these drugs. Compared with official methods, the results obtained were of equal accuracy. A more detailed investigation of th naphazoline-chloranil complex was made with respect to its composition, association constant, and free energy change.

References

Feb 1, 1976·Journal of Pharmaceutical Sciences·J F Alicino
May 1, 1976·Analytica Chimica Acta·B Karlberg, U Forsman
Aug 1, 1974·The Analyst·Y M Dessouky, S A Ismaiel

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