Utility of comorbidity assessment in predicting transplantation-related toxicity following autologous hematopoietic stem cell transplantation for multiple myeloma

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Laura LabontéDavid S Allan

Abstract

Patients with coexisting medical problems may suffer increased toxicity and reduced quality of life after autologous hematopoietic stem cell transplantation (HSCT). The benefit of high-dose therapy for some patients with multiple myeloma (MM) is debatable. Decision tools that aid in identifying those patients with MM most suited for autologous HSCT may avoid the risk of excess toxicity. An objective assessment of comorbidities was performed in 126 patients with MM undergoing autologous HSCT using the Charlson comorbidity index (CCI), the hematopoietic cell transplantation comorbidity index (HCT-CI), and a modified pretransplantation assessment of mortality (mPAM) to determine the strength of association with increased transplantation-related toxicity and increased length of hospital stay (LOS). Any comorbidity scored using the CCI or HCT-CI (score > 0) was associated with an increased number of organ systems with serious toxicity (at least grade 2 toxicity using the Seattle criteria), an increased total sum of toxicity grades for all organs, and prolonged LOS. An mPAM score > or = 24 was associated with increased LOS. When considering autologous HSCT for a patient with MM, assessment of comorbidities using the CCI or HCT-CI may...Continue Reading

References

Feb 1, 1993·Annals of Internal Medicine·J ConcatoT R Holford
May 9, 2003·The New England Journal of Medicine·J Anthony ChildUNKNOWN Medical Research Council Adult Leukaemia Working Party
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip R GreippJan Westin
Mar 22, 2006·Annals of Internal Medicine·Tanyalak ParimonJason W Chien

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Citations

Jan 18, 2011·Hematology·Mohamed L Sorror
Jul 28, 2015·British Journal of Haematology·Holger W AunerNicolaus Kröger
Apr 12, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed L SorrorMarcelo C Pasquini
May 31, 2015·Drugs & Aging·Erica L CampagnaroHillard M Lazarus
May 20, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mohamed L SorrorRainer F Storb
Oct 22, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·William A WoodSergio A Giralt
Jun 29, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicole BirningerJohannes Schetelig
Dec 18, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ayman SaadParameswaran N Hari
Aug 13, 2010·Blood·H Joachim Deeg, Brenda M Sandmaier
Oct 19, 2016·Annals of Hematology·C MartínezUNKNOWN Hodgkin Lymphoma Subcommittee of Spanish Group of Lymphoma and Bone Marrow Transplantation (GELTAMO)
Jul 30, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tanya M WildesSascha A Tuchman
Oct 16, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ulas D BayraktarJoseph L Nates
Mar 14, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Larysa SanchezVictor T Chang
Nov 18, 2017·Clinical Journal of Oncology Nursing·Bojan Kojovic, Joseph D Tariman
Jan 22, 2019·Bone Marrow Transplantation·Gonzalo Gutiérrez-GarcíaJoan Bladé
Oct 6, 2021·Blood Advances·Jesús Duque-AfonsoMonika Engelhardt
Aug 12, 2017·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Rashmika PotdarRoni Shouval

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