Utility of cystatin C as a potential bladder tumour biomarker confirmed by surface plasmon resonance technique

The Indian Journal of Medical Research
Anna TokarzewiczEwa Gorodkiewicz

Abstract

The determination of cystatin C (cysC) may be helpful in diagnosis and monitoring of cancer because the pathogenesis of cancer is linked with an increased activity of cysteine peptidases (cathepsins) and a decrease of cysC concentration. This study was aimed to examine the utility of cysC as a marker of bladder cancer (BCa) to be used in the diagnosis. This study was conducted with 90 patients with BCa and 27 healthy people. Patients with other cancers, inflammation process and impaired renal function were excluded from the study. The concentrations of cysC in the plasma and urine were measured by surface plasmon resonance imaging technique. The concentration of cysC in the serum taken from the patients with BCa [0.35±0.02 μg/ml (range: 0.20-0.78 μg/ml)] was significantly (P<0.001) lower than the serum cysC concentration of the healthy people [0.68±0.05 μg/ml (range: 0.52-0.89 μg/ml)]. The urinary cysC concentration of the BCa patients [0.19±0.01 μg/ml (range: 0.09-0.34 μg/ml)] was not significantly different from the urinary cysC concentration of the healthy people [0.24±0.02 μg/ml (range: 0.16-0.33 μg/ml)]. Receiver operating characteristic (ROC) curve showed that BCa patients with cysC concentration <0.54 μg/ml [sensitivity:...Continue Reading

References

Aug 29, 2013·International Journal of Circumpolar Health·Mariya A DikovskayaTatyana A Korolenko

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Citations

Dec 19, 2018·Biosensors·Ewa Gorodkiewicz, Zenon Lukaszewski
Dec 12, 2020·Journal of Pharmaceutical and Biomedical Analysis·Pawel FalkowskiEwa Gorodkiewicz
Jun 17, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Sara H McDowellChristopher J Scott

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Methods Mentioned

BETA
biosensors
biosensor
surface plasmon resonance

Software Mentioned

MedRoc

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