PMID: 9550317Apr 29, 1998Paper

Utility of deeper sections and special stains for dermatopathology specimens

Journal of Cutaneous Pathology
C P Maingi, K F Helm

Abstract

Special (non-hematoxylin and eosin) stains and deeper sections are routinely used in dermathopathology, although their utility has not been well established. All cases requiring special stains or deeper sections over a three-month period were reviewed to see how often these additional studies contributed to accurate diagnosis. In our series, deeper sections provided diagnostic information to the pathologist in 37.3% [95% confidence interval (CI) 28-46%] of the cases in which they were performed. Deeper sections are more likely to provide a more accurate diagnosis (23.6%, 95% CI 16-32%) rather than establish a new diagnosis not seen on the original sections (13.6%, 95% CI 7-20%). Their use is especially helpful in assessing the presence or absence of cutaneous malignancy rather than in diagnosing inflammatory skin processes. Special stains contributed to the diagnosis in 21.1% (95% CI 11-32%) of cases. When special stains were performed to diagnose an infection they were effective in 14.7% (95% CI 6-24%) of the cases. When special stains were performed to diagnose any other pathologic processes (neoplasm, inflammation, collagen vascular disease, and amyloid) they were effective in 31.8% (95% CI 24-44%) of the cases.

References

Jul 1, 1973·The Laryngoscope·S L Saltzstein, A M Nahum
Aug 1, 1994·The American Journal of Surgical Pathology·D B Troxel, J D Sabella
Apr 1, 1996·Journal of Cutaneous Pathology·A D Rabinowitz, D N Silvers

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Citations

Jan 17, 2004·The American Journal of Dermatopathology·Tamy B H BuckelMichael D Ioffreda
Sep 22, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Oluwole Fadare, Rosemarie Rodriguez
Nov 21, 2013·Journal of Cutaneous Pathology·Lauren N StuartBenjamin K Stoff
Oct 16, 2015·Journal of Cutaneous Pathology·S KipronoH Beltraminelli
Mar 23, 2017·The American Journal of Dermatopathology·Henry R Jakubovic
Apr 15, 2005·Diagnostic Cytopathology·Nancy E JosteSarah L Lathrop
Sep 8, 2000·The American Journal of Surgical Pathology·H M HauptM S Dilaimy
Apr 21, 2016·The American Journal of Dermatopathology·Charlotte LaSenna, Mariya Miteva

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