Utility of DWI with quantitative ADC values in ovarian tumors: a meta-analysis of diagnostic test performance

Acta Radiologica
Shan PiYan Hui Guo

Abstract

Background Diffusion-weighted imaging (DWI) and quantitative apparent diffusion coefficient (ADC) values are widely used in the differential diagnosis of ovarian tumors. Purpose To assess the diagnostic performance of quantitative ADC values in ovarian tumors. Material and Methods PubMed, Embase, the Cochrane Library, and local databases were searched for studies assessing ovarian tumors using quantitative ADC values. We quantitatively analyzed the diagnostic performances for two clinical problems: benign vs. malignant tumors and borderline vs. malignant tumors. We evaluated diagnostic performances by the pooled sensitivity and specificity values and by summary receiver operating characteristic (SROC) curves. Subgroup analyses were used to analyze study heterogeneity. Results From the 742 studies identified in the search results, 16 studies met our inclusion criteria. A total of ten studies evaluated malignant vs. benign ovarian tumors and six studies assessed malignant vs. borderline ovarian tumors. Regarding the diagnostic accuracy of quantitative ADC values for distinguishing between malignant and benign ovarian tumors, the pooled sensitivity and specificity values were 0.91 and 0.91, respectively. The area under the SROC cu...Continue Reading

References

Jul 16, 1999·Radiology·E S Siegelman, E K Outwater
Mar 9, 2002·Journal of Computer Assisted Tomography·Motoyuki KatayamaHiroyuki Kabasawa
Nov 5, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·David M Gershenson
Aug 7, 2004·Human Pathology·Steven G SilverbergRobert H Young
Jul 14, 2006·BMC Medical Research Methodology·Javier ZamoraArri Coomarasamy
Jul 29, 2008·International Journal of Cancer. Journal International Du Cancer·Ingiridur SkírnisdóttirLars Holmberg
Feb 4, 2009·Neoplasia : an International Journal for Oncology Research·Anwar R PadhaniPeter L Choyke
Feb 14, 2009·European Radiology·Isabelle Thomassin-NaggaraMarc Bazot
Jan 23, 2010·AJR. American Journal of Roentgenology·Kumaresan SandrasegaranAlex M Aisen
Oct 19, 2011·Annals of Internal Medicine·Penny F WhitingUNKNOWN QUADAS-2 Group
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray

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