Utility of extended pattern prostate biopsies for tumor localization: pathologic correlations after radical prostatectomy.

Cancer
Ryan T SchulteJohn T Wei

Abstract

Focal targeted therapy has been proposed as a potential treatment for localized prostate cancer in an attempt to reduce morbidity. However, these modalities rely heavily on accurate tumor localization to achieve total tumor ablation. In the current study, we sought to examine the ability of contemporary extended pattern prostate biopsy to predict the location of tumors. A total of 281 men with prostate cancer detected via a standardized extended pattern biopsy template with at least 12 cores and who subsequently underwent radical prostatectomy were evaluated. Tumor location on biopsy, stratified by laterality and by site (apex vs mid-base prostate), was compared with corresponding locations on the prostatectomy specimen. Generalized estimating equation models were developed to assess the effects of clinical variables on pathologic agreement between biopsy and prostatectomy specimens. Of the 281 prostate biopsies, the positive predictive value (PPV) of right and left needle biopsy was high at 97.3% and 96.7%, respectively. However, the negative predictive value (NPV) was low at 24.7% and 31.3%, respectively. When more specific locations were considered, the NPV improved at the apex. However, this came at a cost to the PPV. Tumor...Continue Reading

Associated Clinical Trials

Jun 20, 2018·William Barrett

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Citations

Dec 4, 2008·Asian Journal of Andrology·Nigel Borley, Mark R Feneley
Mar 13, 2010·Future Oncology·Giovanni LughezzaniPierre I Karakiewicz
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Apr 11, 2020·Expert Review of Medical Devices·Luke O'ConnorBaris Turkbey
Jun 26, 2020·World Journal of Urology·Luke P O'ConnorBaris Turkbey

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