Utility of FDG-PET for investigating unexplained plasma CEA elevation in patients with colorectal cancer

Annals of Surgery
F L FlanaganB A Siegel

Abstract

To assess the potential role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose (FDG) in patients with unexplained rising carcinoembryonic antigen (CEA) levels after the treatment of colorectal cancer. A rising CEA level after the resection of colorectal cancer is an early indicator of tumor recurrence. However, conventional imaging techniques have limited sensitivity for detecting recurrent disease in such patients. Especially after surgical intervention, FDG-PET is rapidly gaining an important role in establishing the extent of disease in the oncology patient. Twenty-two patients with abnormal CEA levels and normal results of conventional methods of tumor detection were studied with FDG-PET. The PET results were compared with pathologic findings (n = 9) and long-term radiologic and clinical follow-up (n = 13). FDG-PET was abnormal in 17 of 22 patients. Tissue sampling was available in 7 of these 17 patients; all of these had recurrent disease. Definitive curative surgical intervention was performed in four patients. Subsequent dedicated imaging findings and clinical course confirmed the presence of extensive disease in 8 of the remaining 10 patients; the PET results in the other 2 patients were conside...Continue Reading

References

Sep 1, 1992·Cancer·C J Kelly, J M Daly
Feb 1, 1989·Radiology·L G StraussP Schmidlin
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Northover
Jul 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E J Rutgers
Oct 1, 1995·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·C SchiepersR Aerts
Jun 1, 1995·Diseases of the Colon and Rectum·B OhlssonK G Tranberg
Oct 1, 1994·Seminars in Nuclear Medicine·C E Neal, L C Meis
Mar 1, 1994·Diseases of the Colon and Rectum·J Y WangJ M Chiang
Aug 25, 1993·JAMA : the Journal of the American Medical Association·C G MoertelC Tangen
Jan 1, 1996·American Journal of Surgery·J V VitolaC W Pinson
Aug 1, 1996·Nuclear Medicine and Biology·P S ContiJ R Bading

❮ Previous
Next ❯

Citations

Nov 23, 2000·Diseases of the Colon and Rectum·J S Wu, V W Fazio
Jul 28, 2010·Abdominal Imaging·Yoshiko BambaShingo Kameoka
Aug 19, 2011·Abdominal Imaging·Gaia GrassettoDomenico Rubello
Mar 1, 2012·Abdominal Imaging·A D CulverwellA F Scarsbrook
Aug 29, 2006·International Journal of Clinical Oncology·Keigo EndoKeiko Koyama
Nov 23, 2006·Diseases of the Colon and Rectum·A J M WatsonF A Frizelle
Jun 27, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yolanda Y L YangSteven M Strasberg
Jul 24, 2002·Seminars in Roentgenology·J Vitola, Dominique Delbeke
Aug 12, 2005·Current Surgery·R C Merrell
Mar 23, 2000·Journal of Hepatology·H Bismuth, P E Majno
Jun 5, 2002·European Journal of Radiology·Atadan Tunaci
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Ruers, R P Bleichrodt
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G JerusalemG Fillet
Oct 22, 2003·Surgical Oncology Clinics of North America·Olivier Glehen, François Noël Gilly
Feb 3, 2000·Journal of the American College of Surgeons·P R Fleshner
Jun 29, 2000·Journal of the American College of Surgeons·T AnthonyR H Turnage
Sep 29, 2000·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·M ImbriacoS M Larson
Oct 1, 2003·Clinical Positron Imaging : Official Journal of the Institute for Clinical P.E.T·Perry W. GrigsbyBarry A. Siegel
Mar 21, 2002·The Lancet Oncology·J B BomanjiP J Ell
Feb 13, 2001·The British Journal of Surgery·T H ArulampalamI Taylor
Nov 3, 2010·Clinics in Colon and Rectal Surgery·Adena Scheer, Rebecca Ann C Auer
Feb 3, 2006·The New England Journal of Medicine·Malik E Juweid, Bruce D Cheson
Apr 4, 1998·Annals of Surgery·J E Niederhuber
May 24, 2000·Nuclear Medicine Communications·T O Nunan, S F Hain
Sep 28, 2002·Nuclear Medicine Communications·M SimóI Carrió
Nov 23, 2006·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Lioe-Fee de Geus-OeiWim J G Oyen
Oct 15, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Raghu Vikram, Revathy B Iyer
Dec 25, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A N J TuttM D Leslie
Jun 9, 2007·World Journal of Surgical Oncology·Ismet SarikayaEdward W Martin
Mar 18, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Lale KostakogluStanley J Goldsmith
Apr 30, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M E J PijlJ A van Oostayen

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