Utility of FDG-PET imaging in screening for succinate dehydrogenase B and D mutation-related lesions

Clinical Endocrinology
E R KornaczewskiJ R Burgess

Abstract

Mutations of the genes encoding succinate dehydrogenase B and D (SDHB, SDHD) are associated with highly penetrant phenotypes, including paragangliomas and phaeochromocytomas. Patients with these mutations require lifelong surveillance; however, there is currently ambiguity regarding the optimal screening regimen. We sought to determine the utility of fluorodeoxyglucose (18F) positron emission tomography (18F-FDG PET) imaging, compared to other modalities for detecting SDHB and SDHD mutation-related lesions. A retrospective audit of patients with SDHB or SDHD mutation. All adult patients with confirmed SDHB and SDHD mutations who underwent 18F-FDG PET/CT at our institution between 1 July 2011 and 30 May 2015. 18F-FDG PET/computed tomography (CT) performed during surveillance of patients with SDHB and SDHD mutations. Lesion numbers and locations detected by 18F-FDG PET were compared to those identified on the CT component, as well as other imaging modalities and histology when available. Thirty-one 18F-FDG PET/CT studies were completed on 22 patients. For SDHB (20 patients), there were five positive and 21 negative studies. There were no false-negative 18F-FDG PET studies. Positive 18F-FDG PET findings correlated with magnetic re...Continue Reading

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Citations

Mar 23, 2017·The Journal of Clinical Endocrinology and Metabolism·Elena R Kornaczewski JacksonJohn R Burgess
Apr 13, 2019·Clinical Genetics·Karin EijkelenkampAnouk N A van der Horst-Schrivers
Apr 11, 2019·SAGE Open Medical Case Reports·Dylan A SiejkaAshutosh Hardikar
Dec 22, 2017·Journal of the Endocrine Society·Nicola TuftonScott A Akker
Jul 22, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sangwon HanJong Jin Lee

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