Utility of frozen section analysis on follicular lesions of the thyroid

Endocrine Pathology
Mary P BronnerVirginia A LiVolsi

Abstract

The experience of one surgeon (R.H.) with intraoperative frozen sections (FS) performed on thyroid nodules over a 10-year period was studied to assess the utility of FS in follicular thyroid lesions. One hundred and ten patients with dominant or solitary nodules demonstrating a follicular growth pattern were evaluated. The FS slides and subsequently the permanent sections of the nodules were reviewed by the pathologists in the study (M.P.B., VAL.) without knowledge of the original diagnoses. Our results indicate: (1) if the FS was definitively benign (58 patients), the final diagnosis was benign [these lesions consisted of adenomatous nodule, nodular goiter, follicular adenoma, and Hürthle cell adenoma); (2) if an FS diagnosis of malignancy was rendered (4 patients), it was confirmed on permanent sections (follicular variant of papillary carcinoma in all 4); and (3) if the FS diagnosis was deferred (48 patients), the final diagnosis was benign in all but 10 (21 %) (of these 10, 6 had minimally invasive follicular carcinoma [2 of the Hürthle cell type], and 4 had follicular variants of papillary carcinoma). Overall, sensitivity, specificity, and accuracy rates for FS diagnoses were 29, 100, and 91%. Because unilateral lobectomy ...Continue Reading

Citations

Jun 26, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·M PaesslerZ W Baloch
Apr 16, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sevim TuranliAbdullah Cetin
Aug 24, 2004·Thyroid : Official Journal of the American Thyroid Association·Antonio Ríos ZambudioPascual Parrilla Paricio
Mar 13, 2001·American Journal of Clinical Pathology·E LeteurtreM Lecomte-Houcke
Apr 10, 2009·Thyroid : Official Journal of the American Thyroid Association·Salvatore SorrentiMassimino D'Armiento
Jan 16, 2002·American Journal of Clinical Pathology·Zubair W Baloch, Virginia A Livolsi
Jun 10, 2015·Der Pathologe·S SynorackiK W Schmid
Oct 1, 2004·World Journal of Surgery·Adolfo PisanuAlessandro Uccheddu

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