Utility of Glioblastoma Patient-Derived Orthotopic Xenografts in Drug Discovery and Personalized Therapy

Frontiers in Oncology
Michele PatriziiHatem E Sabaawy

Abstract

Despite substantial effort and resources dedicated to drug discovery and development, new anticancer agents often fail in clinical trials. Among many reasons, the lack of reliable predictive preclinical cancer models is a fundamental one. For decades, immortalized cancer cell cultures have been used to lay the groundwork for cancer biology and the quest for therapeutic responses. However, cell lines do not usually recapitulate cancer heterogeneity or reveal therapeutic resistance cues. With the rapidly evolving exploration of cancer "omics," the scientific community is increasingly investigating whether the employment of short-term patient-derived tumor cell cultures (two- and three-dimensional) and/or patient-derived xenograft models might provide a more representative delineation of the cancer core and its therapeutic response. Patient-derived cancer models allow the integration of genomic with drug sensitivity data on a personalized basis and currently represent the ultimate approach for preclinical drug development and biomarker discovery. The proper use of these patient-derived cancer models might soon influence clinical outcomes and allow the implementation of tailored personalized therapy. When assessing drug efficacy fo...Continue Reading

References

Aug 14, 1999·Journal of Neuropathology and Experimental Neurology·V SennerW Paulus
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Feb 3, 2005·Nature Reviews. Drug Discovery·Alexander Kamb
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Aug 26, 2006·Stem Cells·David Dingli, Franziska Michor
Jul 24, 2007·Nature Reviews. Neuroscience·Rakesh K JainTracy T Batchelor
Oct 24, 2007·International Journal of Cancer. Journal International Du Cancer·Jian WangPer Ø Enger
May 3, 2008·Cancer Research·Chang-Hyuk KwonLuis F Parada
May 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jann N SarkariaWolfgang Wick
Apr 8, 2009·International Journal of Cancer. Journal International Du Cancer·Virginie ClémentIvan Radovanovic
May 12, 2009·Cell Stem Cell·Myung Jin SonHoward A Fine
Feb 4, 2010·PLoS Genetics·Michael James ClarkStanley F Nelson
Mar 20, 2010·Nature Reviews. Cancer·Sreenath V SharmaJeff Settleman
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Mar 31, 2011·Nature Reviews. Clinical Oncology·Lisa Hutchinson, Rebecca Kirk
Nov 9, 2011·Journal of Visualized Experiments : JoVE·Hassan AzariBrent A Reynolds
Apr 18, 2012·Nature Reviews. Clinical Oncology·John J TentlerS Gail Eckhardt
Jun 9, 2012·Neuro-oncology·Peter C HuszthyRolf Bjerkvig
Aug 3, 2012·Nature·Gregory DriessensCédric Blanpain
Feb 26, 2013·Journal of the National Cancer Institute·Jean-Pierre GilletMichael M Gottesman
Apr 19, 2013·Cell Transplantation·Der-Yang ChoLi-Hui Ho
Oct 26, 2013·Cancer Letters·Prerna MalaneyVrushank Davé
Jan 1, 2011·Cancers·Sabrina FacchinoGilbert Bernier
Mar 13, 2014·Cell Stem Cell·Antonija Kreso, John E Dick
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Sep 4, 2014·Cancer Discovery·Manuel HidalgoAlberto Villanueva
Nov 19, 2014·Critical Reviews in Oncogenesis·Dinorah Friedmann-Morvinski
Feb 20, 2015·Molecular Cancer Therapeutics·Monal MehtaHatem E Sabaawy

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Citations

Jan 23, 2020·Journal of the Royal Society, Interface·Inmaculada C SorribesHarsh V Jain
Nov 28, 2019·Radiation Research·Mohammad SakiFrank Pajonk
Jan 10, 2020·CNS Drugs·Ryan D SalinasDonald M O'Rourke
Jun 17, 2020·Neurologia Medico-chirurgica·Tomoyuki KogaFrank B Furnari
Jul 5, 2019·Neuro-oncology·Matthias Holdhoff
Jul 25, 2019·Cells·Christian T StackhouseChristopher D Willey
Sep 23, 2020·Scientific Reports·Anna L KoessingerStephen W G Tait
Apr 25, 2019·Journal of Translational Medicine·Anne ClavreulUNKNOWN FGB network
Oct 3, 2018·Frontiers in Pharmacology·Edouard Alphandéry
Oct 3, 2019·Cells·Cintia Carla da HoraBakhos A Tannous
Feb 16, 2021·Frontiers in Oncology·Ricardo Gómez-OlivaNoelia Geribaldi-Doldán
Mar 23, 2021·Frontiers in Immunology·Darel Martínez BedoyaDenis Migliorini
Apr 4, 2021·International Journal of Molecular Sciences·Colin RaeChiara Braconi
Apr 20, 2021·Frontiers in Oncology·Zhiqin Li, Sigrid A Langhans
May 29, 2020·Cell Stem Cell·Parvez VoraSheila Singh
Jul 25, 2021·International Journal of Molecular Sciences·Joseph AzarWassim Abou-Kheir
Sep 2, 2021·Neuro-oncology Advances·Alexander F HaddadNicholas A Butowski

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Methods Mentioned

BETA
xenograft
surgical resection
xenografts
biopsy

Software Mentioned

IVIS

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