Utility of HE4 to identify patients with endometrioid endometrial cancer who may require lymphadenectomy

Advances in Medical Sciences
Bozena DobrzyckaSlawomir Jerzy Terlikowski

Abstract

The aim of the study was to establish whether preoperative serum levels of HE4 and CA125 could be a good predictor for lymphadenectomy in the early stage of endometrioid adenocarcinoma of the uterus. Preoperative serum HE4 and CA125 were measured in 78 postmenopausal patients treated surgically. The ROC curves were generated to determine the optimal cutoff values of HE4 and CA125 levels with optimum sensitivity and specificity for the prediction of lymphadenectomy. Based on ROC curve, we found that the HE4 value of 78pmol/l is the best cutoff to identify candidates who may require lymphadenectomy with the sensitivity of 86.6% and the specificity of 67.2% (NPV=88.4% and PPV=51.2%). The area under the curve (AUC) equals 0.814 (95% CI=0.721-0.886). The cutoff level of CA125 that shows the prognostic indices is 26U/ml, with the sensitivity of 66.6% and the specificity of 61.2% (NPV=69.4% and PPV=44.3%). For CA125 the AUC amounts to 0.671 (95% CI=0.568-0.764). We also found a statistically significant difference, comparing HE4 and CA125 AUC (0.814 vs. 0.671, respectively, p<0.001). The combination of HE4 and CA125 established in our study as the cutoff point has the sensitivity of 81.2% and the specificity of 65.9% with NPV=83.4% an...Continue Reading

References

Oct 1, 1990·American Journal of Obstetrics and Gynecology·J T SoperR C Bast
Apr 15, 1984·American Journal of Obstetrics and Gynecology·J M NiloffR C Bast
Jan 15, 1999·Gynecologic Oncology·E L TrimbleR C Park
Jul 30, 2002·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S GinathI Avinoach
Mar 2, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Janiel M CragunAndrew Berchuck
Jan 30, 2007·Acta Obstetricia Et Gynecologica Scandinavica·Hyun Hoon ChungHyo-Pyo Lee
Nov 27, 2008·Journal of the National Cancer Institute·Pierluigi Benedetti PaniciCostantino Mangioni
Jun 29, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G PlataniotisUNKNOWN ESMO Guidelines Working Group
Nov 13, 2010·Folia Histochemica Et Cytobiologica·Bożena Dobrzycka, Sławomir J Terlikowski
Jul 2, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Richard G MooreGeralyn Lambert-Messerlian
Oct 20, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Nov 1, 2011·Gynecologic Oncology·Eleftheria KalogeraSean C Dowdy
Jan 25, 2012·Obstetrics and Gynecology·Kimberly K LeslieShujie Yang
Jan 27, 2012·Best Practice & Research. Clinical Obstetrics & Gynaecology·Vivek Arora, Michael A Quinn
Apr 25, 2012·Gynecologic Oncology·Irene Mutz-DehbalaieAndreas Widschwendter
Jul 25, 2012·Obstetrics and Gynecology·Joel I Sorosky
Nov 28, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliPierluigi Benedetti-Panici
Dec 5, 2012·Gynecologic Oncology·Bozena DobrzyckaSlawomir Jerzy Terlikowski
Aug 29, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto AngioliFrancesco Plotti
Sep 17, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Sofie L AntonsenClaus Høgdall
Sep 27, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Roberto AngioliFrancesco Plotti
Mar 7, 2014·Obstetrics & Gynecology Science·Yukio Sonoda
Jun 3, 2014·World Journal of Surgical Oncology·Yachun Bie, Zhenyu Zhang
Jun 7, 2014·Gynecologic Oncology·William M BurkeUNKNOWN Society of Gynecologic Oncology Clinical Practice Committee
Jan 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Stella CapriglioneRoberto Angioli

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Citations

Jul 4, 2015·Journal of Clinical Epidemiology·Lukas J A StalpersAndré L M Verbeek
Mar 10, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea Espiau RomeraLaura Baquedano Mainar
Jul 21, 2016·Journal of Ovarian Research·Katarzyna M TerlikowskaSlawomir J Terlikowski
Nov 7, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Andrea Espiau RomeraLaura Baquedano Mainar

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