Utility of Human Papillomavirus Testing for Cervical Cancer Screening in Korea

International Journal of Environmental Research and Public Health
Mee-Seon KimHyoun Wook Lee

Abstract

(1) Background: Cervical cancer is one of the most common cancers in Korean women. This study was performed to discover the utility of HPV (Human Papillomavirus) testing in screening of cervical lesions and to provide the prevalence of HPV and the genotype distribution in a single center of Korea. (2) Methods: A total of 15,141 women who underwent both HPV testing and cervical cytology were enrolled in this retrospective medical record review study. (3) Results: HPV testing showed higher sensitivity than cytology for the detection of histological high-grade squamous lesions. Furthermore, the sensitivity and specificity of HPV testing varied depending on the method used. The BD Onclarity™ HPV assay had higher sensitivity (90%) than the MyHPV CHIP™ kit (all types of HPV: 82%; high-risk HPV: 76%) for high-grade squamous lesions. A combination of MyHPV CHIP™ and cytology detected 90.9% (30/33) of histological high-grade squamous lesions. A combination of BD Onclarity™ HPV assay and cytology detected 96.55% (84/87) of histological high-grade squamous lesions. In addition, HPV prevalence and genotype distribution were different depending on the HPV testing method used. (4) Conclusion: HPV testing showed higher sensitivity than cytolo...Continue Reading

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Citations

Jun 6, 2020·International Journal of Environmental Research and Public Health·Yueh-Han HsuAnd Chia-Ming Chang

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Methods Mentioned

BETA
hysterectomy
PCR
chips
chip
electrophoresis
genotyping

Software Mentioned

Epi ”
Surepath
epiR
R
R Foundation for Statistical Computing

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