Utility of liquid-based cytology on residual needle rinses collected from core needle biopsy for lung nodule diagnosis.

Cancer Medicine
Zhihua LanFang Yang

Abstract

Core needle biopsy (CNB) has become the most common tissue sampling modality for pathological diagnosis of peripheral lung nodules. However, approximately 10% of pulmonary CNB specimens cannot be unambiguously diagnosed, even with auxiliary techniques. This retrospective study investigated the diagnostic value of liquid-based cytology on residual pulmonary CNB material collected from needle rinses. Computed tomography-guided pulmonary CNB specimens and relevant cytology of CNB needle rinses (CNR) from July 2017 to June 2020 were reviewed. A total of 406 patients, each of whom underwent a CNB procedure, were included in the study. Of the 406 cases, a more serious diagnosis was rendered by CNR in 6.4% (n = 26) of cases. Furthermore, among these 26 cases, 13 malignancies were confirmed only from CNR. Of the remaining 13 patients with uncertain lesions identified from CNR, six were diagnosed with definite benign lesions from tissue samples, five were found to harbor malignant neoplasms through repeated CNB or follow-up examination, and two had tuberculosis. The sensitivity (320/332, 96.4%) of combined CNR/CNB (both CNR and CNB) in distinguishing malignancies from benign lesions was higher than that of CNB alone (307/332, 92.5%). A ...Continue Reading

References

Aug 16, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Carlie S SigelNatasha Rekhtman
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Yuichi SakairiIchiro Yoshino
Jun 21, 2014·Cancer Cytopathology·Leung Chu B TongOscar Lin
Dec 19, 2014·Archives of Pathology & Laboratory Medicine·Natasha RekhtmanJeremy C Durack
Aug 21, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisUNKNOWN WHO Panel
Aug 24, 2016·Archives of Pathology & Laboratory Medicine·Maureen F ZakowskiGüliz A Barkan
Oct 19, 2016·Journal of Thoracic Imaging·Christopher LeeFereidoun Abtin
Apr 22, 2017·Diagnostic Cytopathology·Trupti S PatelPratik Patel

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